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学科：化学. 药学. 生物学

所在单位：生命科学与工程学院

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报考该导师研究生的方式

欢迎你报考田原老师的研究生，报考有以下方式：

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4、如果你有兴趣攻读田原老师博士研究生，可以通过申请考核或者统一招考等方式报考该导师博士研究生。

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论文成果

PUBLICATIONS

(‡ contributed equally; * corresponding author)

27. Wang S., Wu J.*, Tian Y.*, Zhou S. B.* "Tailoring supramolecular antimicrobial peptides: from self-assembled nanoarchitectures to activities." Sci. China Mat., 2024, In press. (IF: 8.100) (co-corresponding author)

26. Song Y., Wang R., Pan Y., Tian Y.*, Zhou S. B.* "An integrated quorum quenching biocatalytic nanoplatform for synergistic chemo-photothermal eradication of P. aeruginosa biofilm infections." Acta. Biomater., 2023, 171, 532-542. (IF: 10.633) (co-corresponding author)

25. Tian Y.‡*, Lu L.‡* "Recent advances in self-assembling peptide matrices as functional coatings for implantable devices." Front. Chem., 2022, 10, 1040499. (IF: 5.545, Invited Review) (contributed equally; co-corresponding author)

24. Fang D., Wang R., Yu X., Tian Y.* "Construction of cyclic cell-penetrating peptides for enhanced penetration of biological barriers." J. Vis. Exp., 2022, 187, e64293. (IF: 1.424, Invited Protocol)

23. Xiao Y., Zhang L., Shi M., Tang R., Jiang Z., Song Y., Tian Y.*, Zhou S. B.* "pH-activatable lactam-stapled peptide-based nanoassemblies for enhanced chemo-photothermal therapy." Nano Res., 2022, 15, 8315-8325. (IF: 10.269) (co-corresponding author)

22. Shi M., Jiang Z., Xiao Y., Song Y., Tang R., Zhang L., Huang J., Tian, Y.*, Zhou S. B.* "Stapling of short cell-penetrating peptides for enhanced tumor cell-and-tissue dual-penetration." Chem. Commun., 2022, 58, 2299-2302. (IF: 6.065) (co-corresponding author)

21. Tang R., Song Y., Shi M., Jiang Z., Zhang L., Xiao Y., Tian Y.*, Zhou S. B., "Rational design of a dual-targeting natural toxin-like bicyclic peptide for selective bioenergetic blockage in cancer cells." Bioconjugate Chem., 2021, 32, 2173–2183. (IF: 6.069)

20. Tian Y., Zhou S. B.*, "Advances in cell penetrating peptides and their functionalization of polymeric nanoplatforms for drug delivery" WIREs Nanomed. Nanobi., 2021, 13, e1668. (IF: 9.423)

19. Ming Y., Xiao Y., Tian Y.*, Zhou S. B.*, “Cell-Membrane Penetration of Tat-Conjugated Polymeric Micelles: Effect of Tat Coating Density.” Macromol. Biosci., 2019, 19, 1800364. (IF: 5.859) (co-corresponding author)







18. Yuan F.‡, Tian Y.‡, Qin W. R.‡, Li J. X., Yang D., Zhao B. C., Yin F.*, Li Z. G.*, “Evaluation of Topologically Distinct Constrained Antimicrobial Peptides with Broad-Spectrum Antimicrobial Activity” Org. Biomol. Chem., 2018, 16, 5764-5770. (IF: 3.890) (contributed equally)

17. Qin. X, Zhao. H, Jiang Y. H., Yin F., Tian Y., Xie M. S., Ye X. Y., Xu N. H., Li Z. G.*, "Development of a potent peptide inhibitor of estrogen receptor α" Chin. Chem. Lett., 2018, 29, 1160-1162. (IF: 8.455)

16. Shi, X. D., Zhao, R. T., Jiang, Y. X., Zhao, H., Tian, Y., Jiang, Y. H., Li, J. X., Qin, W. R., Yin, F.*, Li, Z. G.*,“Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation”Chem. Sci., 2018, 9, 3227-3232. (IF: 9.969)



15. Shi, X. D.‡, Jiang, Y. X.‡, Yang, D.‡, Zhao, H., Tian, Y.*, Li, Z. G.*, “Reversibly Switching the Conformation of Short Peptide through In-Tether Chiral Sulfonium Auxiliary.” Chin. Chem. Lett., 2018, 29, 485-488. (IF: 8.455) (co-corresponding author)



14. Tian, Y.‡, Zeng, X. Z.‡, Li, J. X.‡, Jiang, Y. H., Zhao, H., Wang, D. Y., Huang, X. H.*, Li, Z. G.*, “Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides through Amphiphilicity Tuning.” Chem. Sci., 2017, 8, 7576-7581. (IF: 9.969)



13. Tian, Y.‡, Jiang, Y. H.‡, Li, J. X., Wang, D. Y., Zhao, H., Li, Z. G.*, “Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: a Comparative Study.” ChemBioChem, 2017, 18, 2087-2093. (IF: 3.461) (Inside Back Cover)



12. Li, J. X., Hu, K., Chen, H. L., Wu, Y. J., Chen, L. J., Yin, F.*, Tian, Y.*, Li, Z. G.*, “In-tether chiral center modulates the proapoptotic activity of KLA peptide.” Chem. Commun., 2017, 53, 10452-10455. (IF: 6.065) (co-corresponding author)



11. Zhao H.‡, Qin X.‡, Yang D.‡, Jiang Y. H., Zheng W. H., Wang D. Y., Tian Y., Liu Q. S., Xu N. H.* and Li Z. G.*, “The development of activatable lytic peptides for targeting triple negative breast cancer” Cell Death Discov., 2017, 3, 17037. (IF: 7.109)



10. Jiang, Y. H., Zhao, H., Tian, Y., Li, Z. G.*, “Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems.” Synlett, 2017, 28, 1897-1900. (IF: 2.170)



9. Tian, Y.‡, Yang, D.‡, Ye, X. Y.*, Li, Z. G.*, “Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.” Chem. Rec., 2017, 17, 874-885. (IF: 6.935)



8. Zhao, H., Jiang, Y. H., Tian, Y., Qin, X., Li, Z. G.*, “Improving Cell Penetration of Helical Peptides Stabilized by N-Terminal Crosslinked Aspartic Acids.” Org. Biomol. Chem., 2017, 15, 459-464. (IF: 3.890)





7. Li, J. X., Tian, Y., Wang, D. Y., Li, Z. G.*, “An In-Tether Sulfoxide Chiral Center Influences the Biophysical Properties of the N-Capped Peptides.” Bioorg. Med. Chem., 2016, 25, 1756-1761. (IF: 3.461)


6. Zhang, Q. Z., Jiang, F., Zhao, B. C., Lin, H. C., Tian, Y., Xie, M. S., Bai, G. Y., Gilbert, A. M., Gietz, G. H., Liras, S., Mathiowetz, A. A., Price, D. A., Song, K., Tu, M. H., Wu, Y. J., Wang, T.*, Flanagan. M. E.*, Wu, Y. D.*, Li, Z. G.*, “Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.” Sci. Rep., 2016, 6, 38573. (IF: 4.996)

5. Zhao, H.‡, Liu, Q. S.‡, Geng, H.‡, Tian, Y., Cheng, M., Jiang, Y. H., Xie, M. S., Niu, X. G., Jiang, F., Zhang, Y. O., Lao, Y. Z., Wu, Y. D.*, Xu., N. H.*, Li, Z. G.*, “Cross-Linked Aspartic Acids as Helix-Nucleating Templates.” Angew. Chem. Int. Ed., 2016, 128, 12088-12093. (IF: 16.823)

4. Tian, Y.‡, Wang, D. Y.‡, Li, J. X., Shi, C., Zhao, H., Li, Z. G.*, “A Proline-Derived Transannular N-Cap for Nucleation of Short α-Helical Peptides.” Chem. Commun., 2016, 52, 9275-9278. (IF: 6.065)

3. Tian, Y., Li, J. X., Zhao, H., Zeng, X. Z., Liu, Q. S., Wang, D. Y., Niu, X. G., Huang, X. H., Xu, N. H.*, Li, Z. G.*, “Stapling of Unprotected Helical Peptides via Photo-Induced Intramolecular Thiol-Yne Hydrothiolation.” Chem. Sci., 2016, 7, 3325-3330. (IF: 9.969)

2. Liu, Q. S.‡, Zhao, H.‡, Jiang, Y. H., Wu, M., Tian, Y., Wang, D. P., Lao, Y. Z., Xu, N. H., Li, Z. G.*, “Development of a Lytic Peptide Derived from BH3-Only Proteins.” Cell Death Discov., 2016, 2, 16008. (IF: 7.109)

1. Zhang, Q. Z., Tian, Y., Lao, Y. Z., Li, Z. G.*, “Peptides-Staple Method Development and Its Application in Cancer Therapy.” Curr. Med. Chem., 2014, 21, 2438-2452. (IF: 4.740)

科研项目

- 国家自然科学基金青年科学基金项目，光引发巯基-炔点击化学构建低脱靶双环稳定多肽体系及其生物学应用，21708031，201801-202012，主持；
- 国家博士后创新人才支持计划，基于订书肽的肿瘤深层穿透聚合物纳米载药系统用于乳腺癌治疗，BX20180264，主持；
- 四川省科技创新人才项目，新型环状多肽-药物偶联物的构建及其抗肿瘤活性研究，2023JDRC0028，202301-202512，主持；
- 四川省科技计划苗子工程重点项目，双靶向稳定多肽的构建及其抗乳腺癌活性研究，2020JDRC0051，202001-202112，主持；
- 成都市重点研发支撑计划技术创新研发项目，具有肿瘤靶向能力的双环稳定多肽设计、合成及其抗癌活性研究，2022-YF05-01966-SN，202306-202405，主持；
- 中国博士后科学基金面上项目，基于不同构象的稳定多肽促进纳米载体深层穿透肿瘤组织，2018M643519，主持；
- 深圳湾实验室坪山生物医药研发转化中心基于新颖分子实体的创新药概念验证项目，耐酶解α-螺旋抗菌肽的设计及其抗感染研究，29853MKCJ202300208，202307-202406，主持；
- 成都市医学科研课题，新型构象约束抗菌肽及其偶联药物研究，2023034，20230601-20250531，主持；
- 中央高校基本科研业务费-医工结合培育专项，靶向EGFR的环状多肽前药用于肿瘤免疫治疗，2682023ZTPY045，20230601-20250531，主持；
- 中央高校基本科研业务费-学科交叉研究专项，基于订书肽促进纳米颗粒深层穿透肿瘤研究，2682021ZTPY075，20210601-20230531，主持；
- 中央高校基本科研业务费-科技创新项目，基于促凋亡肽KLA序列的稳定多肽构建及其抗癌活性研究，2682017CX092，20170601-20190531，主持。

个人信息Personal Information

报考该导师研究生的方式

论文成果

PUBLICATIONS

(‡ contributed equally; * corresponding author)

科研项目