田原副教授

硕士生导师

个人信息Personal Information

学科：化学. 药学. 生物学

所在单位：生命科学与工程学院

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4、如果你有兴趣攻读田原老师博士研究生，可以通过申请考核或者统一招考等方式报考该导师博士研究生。

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论文成果

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PUBLICATIONS

(‡ contributed equally; * corresponding author)

27. Wang S., Wu J.*, Tian Y.*, Zhou S. B.* "Tailoring supramolecular antimicrobial peptides: from self-assembled nanoarchitectures to activities." Sci. China Mat., 2024, In press. (IF: 8.100) (co-corresponding author)

26. Song Y., Wang R., Pan Y., Tian Y.*, Zhou S. B.* "An integrated quorum quenching biocatalytic nanoplatform for synergistic chemo-photothermal eradication of P. aeruginosa biofilm infections." Acta. Biomater., 2023, 171, 532-542. (IF: 10.633) (co-corresponding author)

25. Tian Y.‡*, Lu L.‡* "Recent advances in self-assembling peptide matrices as functional coatings for implantable devices." Front. Chem., 2022, 10, 1040499. (IF: 5.545, Invited Review) (contributed equally; co-corresponding author)

24. Fang D., Wang R., Yu X., Tian Y.* "Construction of cyclic cell-penetrating peptides for enhanced penetration of biological barriers." J. Vis. Exp., 2022, 187, e64293. (IF: 1.424, Invited Protocol)

23. Xiao Y., Zhang L., Shi M., Tang R., Jiang Z., Song Y., Tian Y.*, Zhou S. B.* "pH-activatable lactam-stapled peptide-based nanoassemblies for enhanced chemo-photothermal therapy." Nano Res., 2022, 15, 8315-8325. (IF: 10.269) (co-corresponding author)

22. Shi M., Jiang Z., Xiao Y., Song Y., Tang R., Zhang L., Huang J., Tian, Y.*, Zhou S. B.* "Stapling of short cell-penetrating peptides for enhanced tumor cell-and-tissue dual-penetration." Chem. Commun., 2022, 58, 2299-2302. (IF: 6.065) (co-corresponding author)

21. Tang R., Song Y., Shi M., Jiang Z., Zhang L., Xiao Y., Tian Y.*, Zhou S. B., "Rational design of a dual-targeting natural toxin-like bicyclic peptide for selective bioenergetic blockage in cancer cells." Bioconjugate Chem., 2021, 32, 2173–2183. (IF: 6.069)

20. Tian Y., Zhou S. B.*, "Advances in cell penetrating peptides and their functionalization of polymeric nanoplatforms for drug delivery" WIREs Nanomed. Nanobi., 2021, 13, e1668. (IF: 9.423)

19. Ming Y., Xiao Y., Tian Y.*, Zhou S. B.*, “Cell-Membrane Penetration of Tat-Conjugated Polymeric Micelles: Effect of Tat Coating Density.” Macromol. Biosci., 2019, 19, 1800364. (IF: 5.859) (co-corresponding author)

18. Yuan F.‡, Tian Y.‡, Qin W. R.‡, Li J. X., Yang D., Zhao B. C., Yin F.*, Li Z. G.*, “Evaluation of Topologically Distinct Constrained Antimicrobial Peptides with Broad-Spectrum Antimicrobial Activity” Org. Biomol. Chem., 2018, 16, 5764-5770. (IF: 3.890) (contributed equally)

17. Qin. X, Zhao. H, Jiang Y. H., Yin F., Tian Y., Xie M. S., Ye X. Y., Xu N. H., Li Z. G.*, "Development of a potent peptide inhibitor of estrogen receptor α" Chin. Chem. Lett., 2018, 29, 1160-1162. (IF: 8.455)

16. Shi, X. D., Zhao, R. T., Jiang, Y. X., Zhao, H., Tian, Y., Jiang, Y. H., Li, J. X., Qin, W. R., Yin, F.*, Li, Z. G.*,“Reversible stapling of unprotected peptides via chemoselective methionine bis-alkylation/dealkylation”Chem. Sci., 2018, 9, 3227-3232. (IF: 9.969)

15. Shi, X. D.‡, Jiang, Y. X.‡, Yang, D.‡, Zhao, H., Tian, Y.*, Li, Z. G.*, “Reversibly Switching the Conformation of Short Peptide through In-Tether Chiral Sulfonium Auxiliary.” Chin. Chem. Lett., 2018, 29, 485-488. (IF: 8.455) (co-corresponding author)

14. Tian, Y.‡, Zeng, X. Z.‡, Li, J. X.‡, Jiang, Y. H., Zhao, H., Wang, D. Y., Huang, X. H.*, Li, Z. G.*, “Achieving Enhanced Cell Penetration of Short Conformationally Constrained Peptides through Amphiphilicity Tuning.” Chem. Sci., 2017, 8, 7576-7581. (IF: 9.969)

13. Tian, Y.‡, Jiang, Y. H.‡, Li, J. X., Wang, D. Y., Zhao, H., Li, Z. G.*, “Effect of Stapling Architecture on Physiochemical Properties and Cell Permeability of Stapled α-Helical Peptides: a Comparative Study.” ChemBioChem, 2017, 18, 2087-2093. (IF: 3.461) (Inside Back Cover)

12. Li, J. X., Hu, K., Chen, H. L., Wu, Y. J., Chen, L. J., Yin, F.*, Tian, Y.*, Li, Z. G.*, “In-tether chiral center modulates the proapoptotic activity of KLA peptide.” Chem. Commun., 2017, 53, 10452-10455. (IF: 6.065) (co-corresponding author)

11. Zhao H.‡, Qin X.‡, Yang D.‡, Jiang Y. H., Zheng W. H., Wang D. Y., Tian Y., Liu Q. S., Xu N. H.* and Li Z. G.*, “The development of activatable lytic peptides for targeting triple negative breast cancer” Cell Death Discov., 2017, 3, 17037. (IF: 7.109)

10. Jiang, Y. H., Zhao, H., Tian, Y., Li, Z. G.*, “Lipid–Cell-Penetrating-Peptide Conjugates as Effective Delivery Systems.” Synlett, 2017, 28, 1897-1900. (IF: 2.170)

9. Tian, Y.‡, Yang, D.‡, Ye, X. Y.*, Li, Z. G.*, “Thioether-Derived Macrocycle for Peptide Secondary Structure Fixation.” Chem. Rec., 2017, 17, 874-885. (IF: 6.935)

8. Zhao, H., Jiang, Y. H., Tian, Y., Qin, X., Li, Z. G.*, “Improving Cell Penetration of Helical Peptides Stabilized by N-Terminal Crosslinked Aspartic Acids.” Org. Biomol. Chem., 2017, 15, 459-464. (IF: 3.890)

7. Li, J. X., Tian, Y., Wang, D. Y., Li, Z. G.*, “An In-Tether Sulfoxide Chiral Center Influences the Biophysical Properties of the N-Capped Peptides.” Bioorg. Med. Chem., 2016, 25, 1756-1761. (IF: 3.461)

6. Zhang, Q. Z., Jiang, F., Zhao, B. C., Lin, H. C., Tian, Y., Xie, M. S., Bai, G. Y., Gilbert, A. M., Gietz, G. H., Liras, S., Mathiowetz, A. A., Price, D. A., Song, K., Tu, M. H., Wu, Y. J., Wang, T.*, Flanagan. M. E.*, Wu, Y. D.*, Li, Z. G.*, “Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.” Sci. Rep., 2016, 6, 38573. (IF: 4.996)

5. Zhao, H.‡, Liu, Q. S.‡, Geng, H.‡, Tian, Y., Cheng, M., Jiang, Y. H., Xie, M. S., Niu, X. G., Jiang, F., Zhang, Y. O., Lao, Y. Z., Wu, Y. D.*, Xu., N. H.*, Li, Z. G.*, “Cross-Linked Aspartic Acids as Helix-Nucleating Templates.” Angew. Chem. Int. Ed., 2016, 128, 12088-12093. (IF: 16.823)

4. Tian, Y.‡, Wang, D. Y.‡, Li, J. X., Shi, C., Zhao, H., Li, Z. G.*, “A Proline-Derived Transannular N-Cap for Nucleation of Short α-Helical Peptides.” Chem. Commun., 2016, 52, 9275-9278. (IF: 6.065)

3. Tian, Y., Li, J. X., Zhao, H., Zeng, X. Z., Liu, Q. S., Wang, D. Y., Niu, X. G., Huang, X. H., Xu, N. H.*, Li, Z. G.*, “Stapling of Unprotected Helical Peptides via Photo-Induced Intramolecular Thiol-Yne Hydrothiolation.” Chem. Sci., 2016, 7, 3325-3330. (IF: 9.969)

2. Liu, Q. S.‡, Zhao, H.‡, Jiang, Y. H., Wu, M., Tian, Y., Wang, D. P., Lao, Y. Z., Xu, N. H., Li, Z. G.*, “Development of a Lytic Peptide Derived from BH3-Only Proteins.” Cell Death Discov., 2016, 2, 16008. (IF: 7.109)

1. Zhang, Q. Z., Tian, Y., Lao, Y. Z., Li, Z. G.*, “Peptides-Staple Method Development and Its Application in Cancer Therapy.” Curr. Med. Chem., 2014, 21, 2438-2452. (IF: 4.740)