热忱欢迎有志于人类大健康事业的有志青年报考或调剂。常年报考或调剂联系方式：email：maocq@swjtu.edu.cn
Introduction to “Bioinformatics and Innovative Drug Laboratory” (Bio-IDL)
Bio-IDL was founded in 2004 and formerly known as“Laboratory of Molecular Evolution and Applied Biology”(LMEAB). Sponsored by National Natural Science Foundation of China, State Administration of Traditional Chinese medicine, Ministry of Education, Ministry of Science and Technology, Ministry of Housing and urban-rural Development, Department of Housing and urban-rural development of Sichuan province, Southwest Jiaotong University and Yunnan Puer Danzhou Pharmaceutical Company Ltd, our lab has established the molecular evolution and applied biology platforms including bioinformatics and computer aided drug design, biological library and high-throughput screening, and molecular and cellular biology. We had completed more than seventeen research programs including “Studies on the Selection and Display of the High Efficient Heavy Metal-Binding Peptides”, “Combined Control and Remediation of Soil Heavy Metal Pollution with Plant Roots and Microbes Based on Biological Library and Display”, “Rearrangement of Specimens from Folk Medicinal Plants in Natural Reserve”, “Practical Techniques for Rural Waste Water Treatment”, “Bioinformatics and Functional Genomics”, “Laboratory studies of Natural Plant Anti-microbial Solutions”. We had close cooperation and exchanges with both inboard and abroad outstanding scientists’ laboratories including from Chinese Academy of Forestry, Chinese Academy of Medical Sciences/Peking Union Medical College, Academy of Military Medical Sciences, Chinese Academy of Agricultural Sciences.
At present, we had finished the preliminary study of the anti-cancer P201 peptide which is innovative with independent intellectual property right, the joint development of PAMs with entrepreneur had come to the market with multiples functions such as anti-microbial infection and anti-inflammation, analgesia, regeneration, enhancing immunity, anti-cancer and other biological activities. We had published 100 research papers, 37 graduate students were graduated.
Currently, we are particularly interested in the following research areas (1) Screening and development of peptides and small molecules targeting cancers, (2) Development of medicinal plants/folk medicine and mechanisms of molecular/pharmacology.
We accepted graduate candidates both for the major of Biology and Pharmacology. We also accepted PhD candidates for the major of Material Science and Engineering in the area of innovative drugs and carrier material” (Affiliated to the School of Materials Science and Engineering, SWJTU). Welcome both domestic and international students for applying.
Contact：email：maocq@swjtu.edu.cn；For more informations , please see http://userweb.swjtu.edu.cn/Userweb/maocq/index.htm
(1) 茆灿泉*. 食用菌的重金属污染与防治,农业环境与发展,1993,2：34－37。
(2)茆灿泉*. 生物发光细菌lux基因系统的研究进展，国外医学:临床生物化学与检验学分册,1998，19(6)：241-243.
(3)茆灿泉，杨树德，赵玫，范云霞，徐枫,杨华卫，黄常志*.细菌荧光酶报告基因载体构建及在Hela细胞中的表达，微生物学通报, 1999，26(5)：327-332.
(4)黄常志* 周纯 赵玫 施一江 乔绘红 范云霞 茆灿泉 徐枫 袁兴华.反义热休克蛋白90对Hela细胞恶性表型和药敏感性的影响，中华肿瘤杂志，2000，22(1):14-16.
(5)茆灿泉，黄常志*，赵玫，范云霞，徐枫，杜菲，杨树德. HBV启动子调控的GFP在肿瘤细胞中的表达，中国肿瘤生物治疗杂志，2000, 8(1):55-58.
(6)茆灿泉，杨树德*. 发光细菌lux报告基因系统的评价及应用，微生物学通报，2000，27（4）：297-299.
(7)茆灿泉，杨树德，赵玫，范云霞，徐枫，杜菲，杨华卫，袁兴华，黄常志*.细菌荧光酶的融合luxAB基因在肝癌细胞中的表达，中华肿瘤杂志，2001，23(5):359-362.
(8)茆灿泉，薛沿宁*，王会信. 微生物展示技术在重金属生物除污中的应用，生物工程进展，2001, 21(5):48-51.
(9)茆灿泉，黄常志*，杨树德，赵玫，范云霞，徐枫，杜菲. AFP启动子对绿色荧光蛋白在人肝癌细胞中表达的影响，中国医学科学院学报，2001, 23(5):495-498.
(10)辛忠涛，茆灿泉，高亚萍，赵安，张杰，薛沿宁*，凌世淦，柳川等.利用IgA蛋白酶?结构域为骨架构建细菌表面展示随机肽库,生物技术通讯, 2002,13(6):420-423.
(11)Xin ZT, Liu C, Gao YP, Mao CQ, Zhao A, Zhang J, Shao NS, Ling SG, Xue YN*. Identification of mimotopes by screening of a bacterially displayed random peptide library and its use in eliciting an immune response to native HBV-preS ,Vaccine，2003,21(27-28):4373-4379.
(12)An Zhao, Yanning Xue*, Jie Zhang, Bo Gao, Jiannan Feng, Canquan Mao, Li Zheng, Nongle Liu, Fang Wang and Huixin Wang.A conformation-constrained peptide library based on insect defensin A，Peptides,2004，25（4）：629-635.
(13)茆灿泉*,刘畅，马春燕，徐柳，佟鑫，郭泰林，李学如，吴坚.HA结合肽的筛选与序列分析，中国生物工程杂志,2005,25(10)：25-28.
(14)黄敬双，马春燕，佟鑫，易卓林，徐柳，茆灿泉*.Cd2+结合肽的筛选及与重金属离子的亲和作用，微生物学通报，2006，33（5）：70-74.
(15)易卓林，佟鑫，马春燕，黄敬双，茆灿泉*. Ni2＋高效结合肽的筛选与作用研究,微生物学报,2006,46(5):745-748.
(16)Dong J, Liu C,Zhang J, Xin ZT, Yang G, Gao B, Mao CQ, Liu NL, Wang F, Shao NS, Fan M, Xue YN*. Selection of novel nickel-binding peptides from flagella displayed secondary peptide library, Chem Biol Drug Des,2006,68(2):107-12.
(17)谭睿，茆灿泉，李迪强. HPLC指纹技术在自然保护区民族医药植物信息规范化中的应用，中国科技资源导刊，2008，40(5):65-69.
(18)宋良科，茆灿泉，王丽萍，李迪强，谢娟，李小锋，代春初. 四川省自然保护区民族医药植物资源初步调查与整理整合，中国科技资源导刊，2008，40（6）:70-73.
(19)郭志云，茆灿泉，熊莉丽. P53直接调控microRNA及其靶基因的高通量筛选，生物化学与生物物理进展, 2009，36（9）:1154-1164.
(20)郭红光，吴海江，茆灿泉*. 蛋白骨架在随机肽库构建及靶分子筛选中的应用，中国生物工程杂志，2009,29（9）：75-80.
(21)Zhongping Qiu, Yuanyue Liu, Junqiang Zhou, Fei Tong, Canquan Mao, Xiaojing Gu. Effect of Aerating Frequency on Stabilizing Process of Aerobic Bioreactor Landfill, IEEE 2010, 978-1-4244-4713-8/10.
(22)熊莉丽，赵鹏，郭志云，张建华，茆灿泉*. 人α-synuclein突变体的克隆及细菌表面展示，中国老年学杂志，2010，30（17）：2457－2460.
(23)Dashtban, M., Maki, M., Leung, K. T., Mao, C., and Qin, W*. Cellulase Activities in Biomass Conversion: Measurement Methods and Comparison，Critical Reviews in Biotechnology，2010,30(4):302-9.
(24)Xiong LL, Zhao P, Guo ZY, Zhang JH, Li Di-Qiang, Mao Can-quan*. α-synuclein：Gene structure，evolution and in vitro protein aggregation. Neural Regeneration Research,2010,5(18)1423-1428.
(25)郭志云,茆灿泉,熊莉丽. MicroRNA参与下的p53调控网络,中国生物工程杂志,2010,30(11):79-82.
(26)Tingting Huang, Jian Cui, Zhijuan Liang, Damu Wei, Canquan Mao*.Virtual Screening of Lead Chemicals Based on HPX Domain of MT1-MMP,5th International Conference on Bioinformatics and Biomedical Engineering, 2011,DOI: 10.1109.
(27)王利丽,郭红光,王青龙,谭睿,付庆伟,刘娜,洪淑华,沈明珠,余杰,李迪强,茆灿泉*. 鲜猴头菌口服液益智保健功效初步研究，菌物学报，2011，30(1):85-91.
(28)梁志娟，黄敬双，崔健，熊莉丽，茆灿泉*. 双靶向MMP-14和金属离子的结合肽筛选与分子模拟,中国生物化学与分子生物学报,2011, 27(4):341-349.
(29)王薇,王利丽,茆灿泉*. ITS序列作为DNA条形码在虫草鉴定及系统发育关系中的研究与应用，江苏农业学报，2012，28（3）：680-682。
(30)Zhijuan Liang, Jingshuang Huang, Tingting Huang, Jian Cui, Li Zeng, Lili Xiong, Fang Wu，Canquan Mao*. Selection and finding of lead peptides dual-targeting MMP14 and metal ions by subtractive cell surface panning and molecular docking, International Journal of Peptide Research and Therapeutics,2012, 18:31–40.
(31)Bifang He, Canquan Mao, Beibei Ru, Hesong Han, Peng Zhou, and Jian Huang*. Epitope mapping of metuximab on CD147 using phage display and molecular docking, Computational and Mathematical Methods in Medicine, 2013, epub.
(32)Lili Xiong, Zhiyun Guo, Wei Jiang, Rui Zhou, Canquan Mao. Identification and analysis of the regulatory network of Myc and microRNAs from high-throughput experimental data，Computers in Biology and Medicine，2013,6.
(33)Aydarous M, Mao C, Afshan Y, Fadl M A*. 308 tumor necrosis factor α (TNFα) Polymorphism and susceptibility to Typhoid fever in Khartoum State, Sudan Medical Monitor, 2013. 8(2):125-129.
(34)F. Tian*, J. Wu, N.Huang, T.Guo and C. Mao. The critical aggregation concentration of peptide surfactants is predictable from dynamic hydrophobic property, SAR and QSAR in Environmental Research, 2013, 24(2)89-101.
(35)王小波，李学如*，茆灿泉，江南屏，郭泰林. 耐镉马克思克鲁维酵母重金属镉吸附特性的研究, 菌物学报 , 2013(5)。
(36)张远，茆灿泉*.嗜冷黄杆菌酰基-Acp去饱和酶（AAD）的序列分析和结构建模，生物学杂志，2014，31（4）：50-54。
(37)Jian Cui, Jiaming Huang, Tailin Guo, Fang Wu, Zhijuan Liang, Lili Xiong, Tingting Huang, Li Zeng, Na Liu, Canquan Mao*.Expression and Selection of Human Foxm1c Binding Peptides and Their Inhibitions on MCF7 Cancer Cells, Journal of Peptide Research and Therapeutics,2014,20（4）：447-456.
(38)谭博文，周毅洁，黄婷婷，茆灿泉*.靶向MMP14-HPX(HPX14)特异活性位点的确定及反义肽虚拟筛选,生物技术通讯,2014，25(5):40-45。
(39）Lili Xiong, Miranda Maki, Zhiyun Guo, Canquan Mao, Wensheng Qin*. Agave Biomass is Excellent for Production of Bioethanol and Xylitol Using Bacillus strain 65S3 and Pseudomonas strain CDS3, Journal of Biobased Materials and Bioenergy,2014,8,1-7.
(40)曾丽，谭博文，杨亚蓝,邱槿怡，熊莉丽，茆灿泉*. 靶向MT1-MMP反义肽的虚拟筛选与分子模拟，生物工程学报, 2015, 31(2):1−12。
(41)Zongying Liu, Qinglong Wang, Jian Cui, Lili Wang, Lili Xiong,Wei Wang，Diqiang Li，Na Liu, Yiran Wu, Canquan Mao*. Systemic Screening of Strains of the Lion's Mane Medicinal Mushroom Hericium erinaceus (Higher Basidiomycetes) and Its Protective Effects on Aβ-Triggered Neurotoxicity in PC12 Cells,2015,17(3): 219–229.
(42) Bowen Tan, Yijie Zhou, Zhilei Song,Yinxuan Peng, Fang Wu, Yue Kang, Xiaomin Liu, Li Zeng, Tingting Huang, Zongying Liu, Lili Xiong, Zhiyun Guo, Jian Cui, Canquan Mao*. Modeling and Virtual Screening of Antisense Peptides Targeting the Divergent Region of Tumor Associated MT1-MMP Protein，Bulletin of the Korean Chemical Society，2015，36（9）：2198-2207.
(43)毕振飞，宋明珠，刘宗瑛，周毅洁，李迪强，茆灿泉*. 天然植物抗菌液对金黄色葡萄球菌的抑菌作用及机理，生物学杂志，2015，31（4）：50-54。
(44)豆荣昆，毕振飞，白瑞雪，任瑶瑶，谭睿，宋良科，李迪强，茆灿泉*. 黄花紫堇、多刺绿绒蒿及其同属近缘物种的ITS2 DNA条形码鉴定与分析，中国中药杂志，2015，40（7）：15-20。
(45)周毅洁，豆荣昆，毕振飞，杨亚蓝，刘宗瑛，邬怡然，邱槿怡，向飞丹州，茆灿泉*. 一种天然植物抗菌液PAMs对人白血病K562细胞的促凋亡作用，中国药科大学学报，2015，46（6）：712-718。
(46)杨亚蓝，郭志云，丁若凡，茆灿泉*，郭建秀，熊莉丽. 阿霉素诱导下的肝癌细胞HepG2 中微小RNA 差异表达分析, 生物技术通报，2016, 32(6):244-249.
(47) Rao S*, Yao Y, Zheng C, Ryan J, Mao C, Zhang F, Meyre D, Xu Q. Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis，Am J Med Genet B Neuropsychiatr Genet.，2016，Jun 3. Epub ahead of print
(48)Xiong L, Kameshwar AK, Chen X, Guo Z, Mao C, Chen S, Qin W*. The ACEII recombinant Trichoderma reesei QM9414 strains with enhanced xylanase production and its applications in production of xylitol from tree barks，Microb Cell Fact.，2016，15(215):1-18.
(49) Rao S*, Kota LN, Li Z, Yao Y, Tang J, Mao C, Jain S, Xu Y, Xu Q. Accelerated leukocyte telomere erosion in schizophrenia: Evidence from the present study and a meta-analysis, J Psychiatr Res., 2016, 79:50-6.
(50) 豆荣昆，刘宗瑛，白瑞雪，袁雪，张雯雯，向飞丹州，李迪强，茆灿泉*. “紫芸解毒止痛酊”（重）金属含量测定及其镇痛作用机制初探,生物技术通讯，2016，27：（5）670-674。
(51) 邬怡然，毕振飞，黄家明，崔健，茆灿泉*. 靶向FoxM1多肽P201 对人肝癌HepG2细胞的杀伤作用及关键氨基酸分析, 现代生物医学进展, 2017，17(6) : 1024-1028。
(52) Bi Z, Liu W, Ding R, Wu Y, Dou R, Zhang W, Yuan X, Liu X, Xiong L, Guo Z*, Mao C*. A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression，Eur J Pharmacol.，2017,796:175-189.
(53) Dou R, Liu Z, Yuan X, Xiangfei D, Bai R, Bi Z, Yang P, Yang Y, Dong Y, Su W, Li D*, Mao C*. PAMs ameliorates the imiquimod-induced psoriasis-like skin disease in mice by inhibition of translocation of NF-κB and production of inflammatory cytokines，PLoS One. 2017，12(5):e0176823
(54)Liu W, Ding R, Zhang Y, Mao C, Kang R, Meng J, Huang Q, Xiong L, Guo Z*. Transcriptome profiling analysis of differentially expressed mRNAs and lncRNAs in HepG2 cells treated with peptide 9R-P201, Biotechnol Lett., 2017, online.
(55)Rao* S, Yao Y, Ryan J, Jin C, Xu Y, Huang X, Guo J, Wen Y, Mao C, Meyre D, Zhang F. Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations, Sci Rep.，2017, 7: 41140.
(56) 邱槿怡，黄家明，周毅洁，豆荣昆，毕振飞，杨亚蓝，董银松，向飞丹州，茆灿泉*. 一种天然植物抗菌液对人肝癌HEPG-2细胞的杀伤及初步作用机制研究,现代生物医学进展，2017，2017,17（26）：5011-5016。
(57)Diana Kavidia Muyembe, Dou Rong Kun, Song Zhilei, Fang Jin, Xue Yuan, Piao Yang, Zou Jinjing, Mao Can Quan*. Molecular, Chemical and Microscopic Analysis of Medicinal Plant (Cymbopogon distans) from its Adulterants, Journal of Diseases and Medicinal Plants,2018; 4(2): 35-47.
(58)袁雪，邱槿怡，王思怡，豆荣昆，向飞丹洲，郭红萍，杨飘，茆灿泉*.“天然植物抗菌液”(PAMs)对肝癌HepG2细胞的抑制作用及初步分子作用机制, 生物学杂志，2018，已接受。
(59) 宋志磊，韦乐华，袁雪，刘新荣，向飞丹州，李迪强，茆灿泉*.一种“天然植物抗菌液”康人间（KRJ）对LPS诱RAW264.7细胞的抗炎效果及机制初探，现代生物医学进展，2018，18（2）：210-214。
(60) Rao S*, Ghani M, Guo Z, Deming Y, Wang K, Sims R, Mao C, Yao Y, Cruchaga C, Stephan DA, Rogaeva E. An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk，Neurobiol Aging，2018，66:178.e1-178.(61）Jinjing Zou, Rongkun Dou, Danzhou Xiangfei, Diqiang Li, Canquan Mao. Regeneration and Repair of an Acute Thumb Trauma using the Natural Plant Antimicrobial Solution,Clinical Research in Dermatology,2019,2：1-3.
（61）Diana Kavidia Muyembe, Dou Rong Kun, Song Zhilei, Fang Jin, Xue Yuan, Piao Yang, Zou Jinjing, Mao Can Quan*. Molecular, Chemical and Microscopic Analysis of Medicinal Plant (Cymbopogon distans) from its Adulterants, Journal of Diseases and Medicinal Plants, 2018; 4(2): 35-47.
(62) Pei-Chuan Li, Shih-Yi Chen, Danzhou Xiangfei, Canquan Mao, Chieh-His Wu,Jean Chen Shih*. PAMs inhibits monoamine oxidase a activity and reduces glioma tumor growth, a potential adjuvant treatment for glioma, BMC Complementary Medicine and Therapy（SCI）, 2020, 20:252.
(63) Yuhong Jiang*, Xin Zhuo and Canquan Mao，G Protein-coupled Receptors in Cancer Stem Cells，Current Pharmaceutical Design, 2020, 26, 1-12.
(64) Hongping Guo,Yuhong Jiang, Zhiguang Ao,Siyi Wang, Canquan Mao*, A FOXM1‑Targeted Peptide Overcomes 5‑Fluorouracil Resistance via Modulating ABC Transporters in Liver Cancer HepG2 Cells，International Journal of Peptide Research and Therapeutics, 2021, https://doi.org/10.1007/s10989-021-10212-0.
(65)Yuhong Jiang*, Xin Zhuo, Xiujuan Fu, Yue Wu and Canquan Mao*.Targeting PAR2 Overcomes Gefitinib Resistance in Non-Small-Cell Lung Cancer Cells Through Inhibition of EGFR Transactivation, Frontiers in Pharmacology, April 2021,Volume 12: doi: 10.3389/fphar.2021.625289.
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1、参加西南交通大学暑期夏令营活动，提交导师意向时，选择茆灿泉老师，你的所有申请信息将发送给茆灿泉老师，老师看到后将和你取得联系，点击此处参加夏令营活动
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3、参加全国硕士研究生统一招生考试报考茆灿泉老师招收的专业和方向，进入复试后提交导师意向时选择茆灿泉老师。
4、如果你有兴趣攻读茆灿泉老师博士研究生，可以通过申请考核或者统一招考等方式报考该导师博士研究生。
