中文Research
Research Field
Resume
Han Lei, Ph.D., Associate Professor,obtained Bachelor of Biology Education from College of Life Science, Hunan Normal University in June 2000, Master of Microbiology from College of Life & Science, Hunan Normal University in June 2003,and Ph.D. degree of Biomedical Engineering from School of Life Science & Technology, Shanghai Jiaotong University in Nov.2010.He served as a postdoctoral fellow in Department of Biomedical Engineering, in University of Arkansas at Fayetteville and State University of New York at Binghamton from Nov.2011 to May 2015, and joined College of Medicine, Southwest Jiaotong University as a foreign high-level talent in Sep. 2015.
Research
(1) Virus/Bacteria/Cancer Vaccine Delivery Vehicle.
(2) Autoimmune Disease.
Paper Publications
more+- [1] 1. Yi Ren, Xin Lu, Zhonghe Yang, Han Lei*. Protective immunity induced by oral vaccination with a recombinant Lactococcus lactis vaccine against H5Nx in chickens. BMC Veterinary Research, 2022，18(1):3.
- [2] 2. Tong Gao, Yi Ren, Shuangqin Li, Xin Lu, Han Lei*. Immune response induced by oral administration with a Saccharomyces cerevisiae-based SARS-CoV-2 vaccine in mice. Microbial Cell Factories, 2021, 20(1): 95.
- [3] 3. Han Lei*, Xin Lu, Shuangqin Li, Yi Ren. High immune efficacy against different avian influenza H5N1 viruses due to oral administration of a Saccharomyces cerevisiae-based vaccine in chickens. Scientific Reports, 2021,11(1):8977.
- [4] 4. Han Lei*, Shuangqin Li, Xin Lu, Yi Ren. Oral administration of Saccharomyces cerevisiae displaying VP28-VP24 confers protection against white spot syndrome virus in shrimp. Virus Research, 2021, 302: 198467.
- [5] 5. Han Lei*, Tong Gao, Qianhong Cen. Cross-protective immunity of the haemagglutinin stalk domain presented on the surface of Lactococcus lactis against divergent influenza viruses in mice. Virulence, 2021, 12(1): 12-19.
Patents
- [1] 1. 雷涵，林文杰，黄子恩，张炜， 岑黔鸿，一种预防寨卡病毒感染的口服疫苗及其制备方法，授权号：ZL201810373785.5：
- [2] 2. 雷涵，岑黔鸿，高彤，任怡，一种幽门螺杆菌口服疫苗，受理号：202010569240.9 （实审）：
- [3] 3. 雷涵，岑黔鸿，林文杰，张 炜， 一种预防 H7N9 病毒感染的口服疫苗及其制备方法。受理号：201810614228.8（实审）：
- [4] 4. 雷 涵，高彤，任怡，基于酵母表面展示系统的 COVID-19 亚单位疫苗，受理号：202010594705.6，（实审）：
- [5] 5. 雷涵，高彤，任怡，鲁欣，基于昆虫杆状病毒表达系统构建 COVID-19 亚单位疫苗的方法，受理号：202010594705.6，（优先权申请）：
Published Books
- [1] 1. 雷涵（主编）, 樊梅（副主编），研究生教材《肿瘤免疫治疗概论》（英文版），西南交通大学出版社、2020年10月、ISBN: 978-7-5643-7752-6。.
- [2] 2. 雷涵（著），乳酸乳球菌作为禽流感病毒疫苗递送载体的研究，西南交通大学出版社 ，2021年7月， ISBN: 978-7-5643-8102-8。.
- [3] 3. Han Lei, Tong Gao, Yusuf Hamied, John Howard, Jie Liu, Rob Davidson, Raymond Tong, Olivia Yee Lam, Fong W Lam, Dominic Man-Kit Lam*，Book: Biotechnology in Hongkong Chapter 8: The development of a yeast-derived oral vaccine against Hepatitis B. 2020, Volume IV: 123-134. ，UNITED STATES-CHINA INTELLECTUAL PROPERTY INSTITUTE INC. WHITESHTONE, NEW YORK, 2020年11月。.
Research Projects
more+- [1] 1. 国家自然科学基金面上项目，基于酿酒酵母表面展示技术构建寨卡病毒口服疫苗及其免疫机理研究，项目编号：32070920，2021.01-2024.12，58 万，主持。
- [2] 2. 四川省科技厅重点研发项目，酿酒酵母表面展示技术应用于高致病性禽流感口服疫苗的研究，项目编号：2019YFN0134，2019.01-2021.12，30 万，在研，主持。
- [3] 3. 深圳虚拟大学园自由探索类基础研究项目，COVID-19新型亚单位蛋白疫苗的研发，项目编号：2021Szvup121，2021.08-2023.07， 20万，在研，主持。
- [4] 4. 中央高校基本科研业务费基础研究培育专题研究项目，新冠病毒 S 蛋白和 RBD 作为新型 疫苗靶点的研究，项目编号：2682020ZT87，2020.11-2022.11, 8 万，在研，主持。
- [5] 5. 中央高校基本科研业务费科技创新项目，基于酿酒酵母表面展示系统构建寨卡口服的免疫活性研究，项目编号：2682018CX73，2018.01-2020.12，10 万，结题，主持。
Han Lei
Associate Professor
Supervisor of Doctorate Candidates
Supervisor of Master's Candidates