高峰，男，博士，教授，博士研究生导师，西南交通大学生命学院副院长，四川省学术技术带头人后备人选，四川省药学类专业教学指导委员会委员，四川省制药工程类专业教学指导委员会委员，《天然产物研究与开发》和《生物学杂志》编委。2002年毕业于四川大学华西药学院药学专业，获药学学士-学位，2005年毕业于四川大学华西药学院，获药物化学硕士学位。2009年在四川大学华西药学院获天然药物化学博士学位，同年进入四川农业大学农学院中草药栽培与鉴定教研室，从事科研及教学工作，2013年8月至2014年8月在美国宾夕法尼亚大学化学系Patrick J. Walsh课题组访学，2016年9月进入西南交通大学生命科学与工程学院。主要研究领域为金属/光催化的天然稀有活性化合物的高效仿生转化合成、结构优化及活性评价，基于Late-Stage Modification策略的天然药物直接结构修饰，以及基于AI新算法的小分子活性化合物的设计合成。主持国家自然科学基金面上项目3项，自然基金青年项目、教育部博士点基金和四川省科技支撑计划各1项。在天然药物化学领域的权威期刊《Sci. Adv.》《J. Am. Chem. Soc.》, 《Angew. Chem. Int. Ed.》《Chem. Sci.》,《Chem. Comm.》, 《Org. Lett.》, 《J. Org. Chem》《Org. Biomol. Chem.》,《J. Nat. Prod.》, 《Fitoterapia》,《Phytochemistry》等以发表论文100多篇，均被SCI收录，授权专利2项。参与获得国家级教学成果二等奖及教育部自然科学一等奖。

近三年代表论文：

2024年度

1. Wei Cheng, Steven De Jonghe, Dominique Schols, Xiaohuan Li, Jin-Bu Xu, and Feng Gao*, Crownane, A Novel Diterpene from Euphorbia lathyris: Structural Elucidation, Bioinspired Semi-synthesis and Anti-HIV Activity Evaluation, Angew. Chem. Int. Ed., 2024, Under Review.

2. Neng Wang, Lin-Xi Wan, Xiaohuan Li, Jin-Bu Xu, and Feng Gao*, Rapid Access to Tigliane, Ingenane, and Rhamnofolane Diterpenes from a Lathyrane Precursor via Biomimetic Skeleton Transformation Strategy, J. Nat. Prod., 2024, 87, 1479-1486.

3. Lian Sun, Xin-Ming Wang, Qianhui Tang, Yao Xiao, Jin-Bu Xu, Tong-Tong Zhang, Yan-Jun Liu, Xiaohuan Li, Feng Gao*, Lathyrane and premyrsinane Euphorbia diterpenes against Alzheimer's disease: Bioinspired synthesis, anti-cholinesterase and neuroprotection bioactivity, Bioorg. Chem., 2024, 147, 107377.

4. Rui Feng, Yong-Qi Zhen, Lian Sun, Jin-Bu Xu, Xiao-Huan Li, Lan Zhang, Feng Gao*, Base-Controlled Pd-catalyzed Regioselective Synthesis and Bioactiv-ity of Arylated Osimertinib Derivates, Sci. Adv., 2024, 10, eadl0026.

5. Wei Cheng, Jin-Bu Xu, Ming-Hao Guo, Xiao-Huan Li, Yan Li, Gao, Feng*, Bronsted Acid-Mediated Conversion of Naturally Abundant Lathyrane Diterpenes: Are Rare 10,11-seco-Lathyrane Diterpenes Artifacts? J. Nat. Prod., 2024, 87, 113–120.

6. Sihao Deng, Huanqiu Wu, Nian Du, Jin-Bu Xu, Xiaohuan Li, Dong-Mei Fang, Feng Gao*, Light-promoted AIBN-catalyzed oxidative cleavage of aryl olefins to aryl ketones, Tetrahedron, 2024, 166, 134211.

7. Ling Huang, Lin-Yu Huang, Lian-Hai Shan, Feng Gao*, Ling-Li Zheng*, Jin-Bu Xu*, Design, Synthesis, and Antifeedant Activity Evaluation of 13/14-Arylthioether Matrine Derivatives, ACS Omega, 2024, 9, 38169–38179.

8. Xiao-Xing Zhu, Feng Gao*, Lin-Xi Wan*, Design, synthesis and anti-Alzheimer's disease activity evaluation of C-3 arylated huperzine A derivatives, Fitoterapia, 2024, 177, 106141.

9. Qianhui Tang , Yougan Lu, Junying Song, Zhengyang He, JinBu Xu, Jiao Tan, Feng Gao*, Xiaohuan Li*, Light-promoted stereoselective late-stage difunctionalization and anti-tumor activity of oridonin, 2024, 177, 106131

2023年度

1. Jin-Bu Xu, Peng Wen, Neng Wang, Xiaohuan Li, Jia-Hong Li, Steven De Jonghe, Dominique Schols, and Feng Gao*, Photo-induced Scandium-catalyzed Biomimetic Skeleton Conversion of Lathyrane to Eupholathone-type Euphorbia Diterpenes, Chem. Commun., 2023, 59, 12290–12293.  

2. Bo Yin, Xiao-Huan Li, Zi-Xiang Li, Xiao-Xin Zhu, Lan Zhang, Feng-Zheng Chen, Pei Tang, and Feng Gao*, Adenophorone, an Unprecedented Sesquiterpene from Eupatorium adenophorum: Structural Elucidation, Bioinspired Total Synthesis and Neuroprotective Activity Evaluation, Angew. Chem. Int. Edit. 2023, e202306326. (Highlighted by Synfactes (2023, 19, 0931), Nat. Prod. Rep. (2023, 40, 1590))

3. Wenke Jin, Jin Zhang, Xiya Chen, Siwen Yin, Haiyang Yu*, Feng Gao*, Dahong Yao*, Unraveling the complexity of histone-arginine methyltransferase CARM1 in cancer: From underlying mechanisms to targeted therapeutics, BBA-Rev. Cancer, 2023, 1878, 188916.

4. Ming-Hao Guo, Peng Wen, Yao Xiao, Wan-Sheng Ji, Xian-Li Zhou, Lian-Hai Shan*, Feng Gao*, Design, Synthesis and Anti-inflammatory Activity of Diterpenoid Alkaloids and Non-steroidal Anti-inflammatory Drug Hybrids based on Molecular Hybridization Strategy, Fitoterapia 2023, 168, 105536.  

5. Yao Xiao, Yang Zhang, Wan-Sheng Ji, Xiao-Nan Jia, Lian-Hai Shan, Xiaohuan Li, Ting Jiang, Feng Gao*, Discovery of myrsinane-type Euphorbia diterpene derivatives through a skeleton conversion strategy from lathyrane diterpene for the treatment of Alzheimer's disease, Bioorg. Chem., 2023, 138, 106596.

6. Neng Wang, Hang Wang, Lin-Xi Wan, Xiao-Huan Li, Xian-Li Zhou, Jia-Hong Li, Steven De Jonghe, Dominique Schols, Jin-Bu Xu, and Feng Gao*, Visible-Light-Promoted Tandem Thiol−Ene Click Reaction/Transannular Cyclization and Regioselective Cyclopropane Ring-Opening to Construct Sulfur-Containing Euphorbia Diterpenes, Org. Lett., 2023, 25, 597−602.

7. Yang Zhang, Jin-Bu Xu, Yao Xiao, Wan-Sheng Ji, Lian-Hai Shan, Lin-Xi Wan, Xian-Li Zhou*, Yu Lei*, and Feng Gao*, Palladium-Catalyzed Synthesis, Acetylcholinesterase Inhibition, and Neuroprotective Activities of N-Aryl Galantamine Analogues, J. Nat. Prod., 2023, 86, 939-946.

8. Zhen-Xiang He, Bo Yin, Xiao-Huan Li, Xian-Li Zhou, Hai-Ning Song*, Jin-Bu Xu*, and Feng Gao*, Photochemical Selective Oxidation of Benzyl Alcohols to Aldehydes or Ketones, J. Org. Chem., 2023, 88, 4765-4769.

9. Jin-Bu Xu, Shi-Xing Miao, Feng Gao*, and Lin-Xi Wan*, Palladium-catalyzed synthesis and acetylcholinesterase inhibitory activity evaluation of 1-arylhuperzine A derivatives, J. Asian. Nat. Prod. Res., 2023, 25, 1097-1109.

10. Jin-Bu Xu, Jin Bi, Peng Wen, Shi-Xing Miao, Xiao-Huan Li, Feng Gao*, Synthesis and Cytotoxicity Evaluation of Dehydroepiandrosterone Derivatives by Iron-catalyzed Stereoselective Hydroamination, Chem. Pharm. Bull., 2023, 71 349-353.

11. Lian Sun, Rui Feng, Yong-Qi Zhen, Zong-Rui Hou, Xiaohuan Li, Lian-Hai Shan*, Feng Gao*, Exploration of anti-tumor activity of erlotinib derivatives enabled by a Pd-catalyzed late-stage Sonogashira reaction, Tetrahedron, 2023, 133237.

12. Yao Xiao, Wan-Sheng Ji, Wen-Ke Jin, Peng Wen, Lian-Hai Shan, Zong-Rui Hou, Xiao-Huan Li, Xian-Li Zhou, Yan-Jun Liu, Jin-Bu Xu, Feng Gao*, Synthesis, Antiproliferative and Anti-MDR Activity of Lathyrane Diterpene Derivatives Based on Configuration Inversion Strategy, Bioorg. Chem., 2023, 131, 106329.

13. Lan Zhang, Yuling Zou, Yingying Lu, Zhijia Li, Feng Gao*, Unraveling the therapeutic potential of carbamoyl phosphate synthetase 1 (CPS1) in human diseases, Bioorg. Chem., 2023, 130, 106253.

2022年度

1. Neng Wang, Jin-Bu Xu, Xiao-Huan Li, Xian-Li Zhou, and Feng Gao*, Ir-Catalyzed Biomimetic Photoisomerization of Cyclopropane in Lathyrane-Type Euphorbia Diterpenes, Org. Lett., 2022, 24, 8598−8602.

2. Wei Cheng, Jin-Bu Xu, Neng Wang, Peng Wen, Xian-Li Zhou, and Feng Gao*, Scandium-Catalyzed Skeleton Conversion of Lathyrane to Lathyranone-Type Euphorbia Diterpenes, J. Org. Chem., 2022, 87, 13411−13415.

3. Yuzhu Li, Yushan Shang, Xiaohuan Li, Yinyong Zhang, Jiang Xie, Lin Chen*, Feng Gao*, Xian-Li Zhou*, Design, synthesis, and biological evaluation of low-toxic lappaconitine derivatives as potential analgesics, Eur. J. Med. Chem., 2022, 243, 114776.

4. Lin-Yu Huang, Jin-Bu Xu, Xiang-Yu Li, Hai-Ning Song, Lin Chen,* Xian-Li Zhou,* and Feng Gao*, Palladium-Catalyzed Direct Synthesis and Insecticidal Activity of Arylmatrine Derivatives, J. Nat. Prod., 2022, 85, 2026−2034.

5. Xiao-Nan Jia, Wei-Jia Wang, Bo Yin, Lin-Jing Zhou, Yong-Qi Zhen, Lan Zhang, Xian-Li Zhou, Hai-Ning Song,* Yong Tang,* and Feng Gao*, Deep Learning Promotes the Screening of Natural Products with Potential Microtubule Inhibition Activity, ACS Omega, 2022, 7, 28334−28341.

6. Yan-Zuo Chen, Neng Wang, Zong-Rui Hou, Xian-Li Zhou, Xiaohuan Li, Feng Gao*, Ting Jiang*, Palladium-catalyzed stereoselective ring-opening reaction of aryl cyclopropyl ketones, Org. Biomol. Chem., 2022, 20, 5412-5415.

7. Yufeng Du, Linyu Huang, Neng Wang, Xiaohuan Li, Xian-Li Zhou, Lan Zhang, Shuai Huang,* Patrick J. Walsh*, Feng Gao*, Rhodium-Catalyzed Direct Arylation of Furopyridine: Synthesis and the Cardiac Effects of Dictamnine Derivatives, Adv. Synth. Catal., 2022, 364, 1002-1008 

获奖情况：

1. 以研为中心的工程类研究生创新能力培养体系构建与实践   

国际级教学成果二等奖（2023年  排名第7）

2. 药用草乌化学成分的系统研究    

教育部自然科学一等奖（2015年  排名第12）          

3. 两个结构简化的紫杉醇类似物的设计、合成及抗癌活性研究

第十三届全国大学生“挑战杯”课外学术竞赛全国现场决赛 

三等奖（ 2013年  指导老师） 

4. 雅安特产汉源乌头中抗癌生物碱成分研究

第十二届全国大学生“挑战杯”课外学术竞赛全国现场决赛 

三等奖（2011年  指导老师）

5. 国产乌头属植物药用亲缘学研究

第五届中国科协期刊优秀学术论文奖一等奖（ 2007年）

主持科研项目：

1. 基于仿生骨架转化的天然稀有曼西烷二萜结构修饰及抗三阴性乳腺癌机制研究

----国家自然科学基金面上项目  2023.1-2026.12

2.基于构型翻转的抗肿瘤续随子二萜结构修饰、构效关系及作用机制研究

----国家自然科学基金面上项目  2019.1—2022.12

3.结构简化的紫杉醇模拟物的设计、合成及活性研究 

----国家自然科学基金面上项目  2016.1—2019.12

4.基于天然产物的小分子微管稳定剂的设计、合成及抗癌活性研究

----四川省科技厅支撑计划   2015.1—2017.12

5.简化紫杉醇的合成及抗癌活性研究

----留学归国人员启动基金优先资助    2016.1—2017.12

6.新一代紫杉醇类似物的设计、合成及活性研究

----国家自然科学基金青年基金   2011.1—2013.12 

7. 新型紫杉醇衍生物的合成及抗癌活性评价

----教育部博士点新教师基金   2011.1—2013.12

8.草乌甲素结构修饰及镇痛活性研究

----四川省教育厅青年基金   2010.1—2012.12

9. 四川农业大学“高端人才”人才基金资助

----四川农业大学   2010—2016

课题组学生风采：

• 天然抗肿瘤、抗HIV及抗AD药物的发现及其结构修饰
• AI指导的小分子药物的发现、合成及作用机制
• 金属催化的小分子药物Late-stage结构修饰及活性筛选