课题组目前主要有四个研究大方向/There are currently four research streams carried out in the FAN group.  

1. 基于贵金属纳米材料的环境和生物医学分析化学，包括环境污染溯源，环境污染物分析分离方法研究，以及食品和公共安全的现场快速分析方法/Coinage metallic nanomaterials based environmental and biomedical analytical chemistry;

环境污染和污染物溯源具有十分重要的现实意义和科学价值。例如，工业园区中排污溯源有助于环境执法部门执法。污染物的溯源则有助于环境科学家们认识污染物在环境中的迁移转化途径和最终归宿。另一方面，食品和公共安全中有害污染物的快速检测则具有十分重要的现实意义。表面增强分子振动光谱，如表面增强红外（SEIRA）和表面增强拉曼（SERS）是在有贵金属纳米材料存在下可以观察到的现象，且都具有极高的灵敏度和化合物的指纹特性。它们是环境检测和溯源的有力武器。

本方向也关注医学相关领域的检测，如抗癌药物和抗生素等在体液内的浓度和动力学曲线监测等。

2. 绿色化学，特别是基于纳米材料的杀菌和杀病毒新型材料研究/Functional materials for bacteria and virus disinfection;

本方向主要关注研制新型杀菌、杀病毒材料，应用于分散式饮用水处理（point of use water disinfection）和公共交通环境（如车厢内）和人流密集场所（如车站等）等的杀菌涂层。

3. 污染物表界面化学研究/Heterogeneous chemical processes on particulate matter pollutants;and

表界面是污染物发生二次转化的关键场所，研究在这个界面上的化学变化和化学反应对理解污染物的环境行为具有极为重要的意义。本方向主要利用表面增强分子振动光谱对发生在界面的化学过程进行原位表征。

4. 基于COMS相机成像环境分析化学/COMS camera based analytical chemistry.

智能手机几乎是目前最为普及的电子产品。但其功能并不仅仅局限于打电话和拍照上网。利用手机的摄像头和本身的数据处理能力，可以研发出各种便携的分析检测设备。

Selected publications

Link to up-to-date citation

2024年

86. Y. Zhao, Y. Li, Y. Liu, D. Wang and M. Fan*, Electrochemiluminescence detection of Hg2+ using lanthanide mental organic gel based on boric acid functionalization, Microchemical Journal, 2024, DOI: 10.1016/j.microc.2024.111506

85. Liu, S.; Wang, C.; Yang, P.; Wang, D.; Gong, Z.; Hu, J.; Xiong, C.; Fan, M.* Smartphone-Assisted Three Dimensional-Printed Acute Toxicity Detection: Mitigating the Impact of Sample Color. ACS ES&T Water 2024, 4 (6), 2587-2596. 

84. Chao, S.; Valsecchi, C.; Sun, J.; Shao, H.; Li, X.; Tang, C.; Fan, M.* Highly Sensitive Surface-Enhanced Raman Scattering Detection of Hydroxyl Radicals in Water Microdroplets Using Phthalhydrazide/Ag Nanoparticles Nanosensor. Environ. Sci. & Techn. 2024. DOI: 10.1021/acs.est.4c03081.

83. Ma, N.; Liu, S.; Zhou, S.; Wang, D.; Gong, Z.; Fan, M.* Label-Free Surface-Enhanced Raman Scattering-Based Microbial Whole-Cell Biosensor for Acute Toxicity Assessment in Water. ACS ES&T Water 2024, 4 (5), 2204-2211.

82.  Wang, X.; Li, F.; Wei, L.; Huang, Y.; Wen, X.;  Wang, D.;Yang, H.; Fan, M.*. Rapid and Precise Differentiation and Authentication of Agricultural Products via Deep Learning-Assisted Multiplex SERS Fingerprinting. Anal Chem. 2024, 96 (11), 4682-4692. 

81. Liu, S., Tang, C., Jiang, K.;  Zhang, L.;  Ma, N.;  Li, Y.;  Fan, M.*; Huang, B.. Toxicity of energetic nanomaterials assessed on L929 fibroblasts. Chem. Pap. (2024). https://doi.org/10.1007/s11696-024-03324-6

80. Gao, W.; Fan, W.; Wang, D.; Sun, J.; Li, Y.; Tang, C.; Fan, M.* Assessing fresh water acute toxicity with Surface-Enhanced Raman Scattering (SERS). Talanta 2024, 267, 125163.  (IF=6.1, JCR Q1)

2023年

79. Wang, X.; Liu, X.; Li, F.; Valsecchi, C.; Hu, Z.; Zhang, Y.; Wang, D.; Wang, C.; Sun, J.; Fan, M.*. Multifunctional 3D magnetic carbon aerogel for adsorption separation and highly sensitive SERS detection of malachite green. Chemosphere 2023, 339, 139654. (IF=8.8, JCR Q1)

78. Li, J.; Wang, X. H.; Tang, J. X.; Li, F.; Wang, X. Q.; Muhammad, T. A. D.; Hu, Z. M.; Wang, D. M.; Gong, Z. J.; Fan, M.*. Fingerprinting and Differentiation of Landfill Leachate and Domestic Sewage in Surface Water with Machine Learning Based Surface Enhanced Raman Spectroscopy. ACS ES&T Water 2023. DOI: 10.1021/acsestwater.3c00441 (IF=5.3, JCR Q1).

77. Gao, W.; Duan, W.; Peng, D.; Li, J.; Hu, Z.; Wang, D.; Gong, Z.; Fan, M.* Surface-enhanced Raman Scattering (SERS) microbial sensor for fresh water acute toxicity monitoring. Microchem. J. 2023, 191, 108822. 

76. Chao, S.; Shao, H.; Wang, X.; Zhang, Y.; Jiang, R.; Fan, M.*; Chen, S.; Tang, C*. Plasmon-Driven Photochemical Reduction Reaction on Silver Nanostructures for Green Fabrication of Superhydrophobic Surface. Small 2023, n/a (n/a), e2303536. DOI: 10.1002/smll.202303536.  (IF=13.3, JCR Q1)

75. Zeng, B.;  Wang, X.; Fan, M.*, Facile fabrication of field deployable surface enhanced Raman scattering smart sand from sea sand. Mater. Lett. 2023, 333, 133655.

74. Li, F.;  Huang, Y.;  Wang, X.;  Wang, D.; Fan, M.*, Surface-enhanced Raman scattering integrating with machine learning for green tea storage time identification. Luminescence 2023.

73. Huang, Y.;  Yuan, B.;  Wang, X.;  Dai, Y.;  Wang, D.;  Gong, Z.;  Chen, J.;  Shen, L.;  Fan, M.*; Li, Z., Industrial Wastewater Source Tracing: The Initiative of SERS Spectral Signature Aided by a One-dimensional Convolutional Neural Network. Water Res. 2023, 119662.  (IF=12.8, JCR Q1)

72. Hu, Z.;  Peng, D.;  Xing, F.;  Wen, X.;  Xie, K.;  Xu, X.;  Zhang, H.;  Wei, F.;  Zheng, X.; Fan, M.*, Iodine-Modified Ag NPs for Highly Sensitive SERS Detection of Deltamethrin Residues on Surfaces. Molecules 2023, 28 (4).

2022年

71. Zeng, B.;  Huang, Y.; Fan, M.*, Interference Free HPLC-SERS for the Trace Analysis of Residual Furazolidones in the Aquaculture Sediment. Chemosensors 2022, 10 (12).

70. Peng, D.;  Hu, Z.;  Zheng, W.;  Pang, X.;  Wang, D.; Fan, M.*, Ameliorating SERS Sensitivity for Pesticide Malathion Detection with Synergistic Boosting Effect by Hydrogen Cations and Chloride Anions. Langmuir 2022, 38 (50), 15656-15661.

69. Zhou, S.;  Hu, Z.;  Zhang, Y.;  Wang, D.;  Gong, Z.; Fan, M.*, Differentiation and identification structural similar chemicals using SERS coupled with different chemometric methods: The example of fluoroquinolones. Microchem. J. 2022, 183.

68. Wang, D.;  Hui, B.;  Zhang, X.;  Zhu, J.;  Gong, Z.; Fan, M., Facile Preparation of Ag-NP-Deposited HRGB-SERS Substrate for Detection of Polycyclic Aromatic Hydrocarbons in Water. Chemosensors 2022, 10 (10).

67. Wang, D.;  Gong, Z.;  Tang, M.;  Fan, W.;  Huang, B.; Fan, M., Halogen ion modified Ag NPs for ultrasensitive SERS detection of nitroaromatic explosives. Anal Methods 2022, 14 (38), 3798-3801.

66. Li, F.; Wang, X.; Zhou, S.; Wang, D.; Gong, Z.; Fan, M.*, A Multi-dimensional Surface-Enhanced Raman Scattering (SERS) Strategy for Tea Differentiation, ACS Food Science & Technology, 2022, 2 (7), 1096-1102..

65. Wei, L.; Liu, W.; Zhu, C.; Wang, D.; Gong, Z.; Fan, M.*, Assessing the effect of different pH maintenance situations on bacterial SERS spectra. Anal and Bioanal Chem 2022, 414 (17), 4977-4985.(IF=4.142, JCR Q1 in analytical chemistry)

64. Zhu, C.; Liu, W.; Wang, D.; Gong, Z.; Fan, M.*, Boosting bacteria differentiation efficiency with multi-dimensional surface-enhanced Raman scattering: the example of Bacillus cereus. Luminescence 2022, DOI: 10.1002/bio.4268.

63. Liu, W.; Wei, L.; Wang, D.; Zhu, C.; Huang, Y.; Gong, Z.; Tang, C.; Fan, M.*, Phenotyping Bacteria through a Black-Box Approach: Amplifying Surface-Enhanced Raman Spectroscopy Spectral Differences among Bacteria by Inputting Appropriate Environmental Stress. Anal Chem 2022,94(18): 6791-6798. (IF=6.986, JCR Q1 in analytical chemistry)

62. Liu, B.; Huang, Y.; Zheng, W.; Wang, D.; Fan, M., A SERS pH sensor for highly alkaline conditions and its application for pH sensing in aerosol droplets. Anal Methods 2022, DOI: 10.1039/D2AY00387B. (IF=2.896, JCR Q3 in analytical chemistry)

61. Fan, W., Gao, W., Jiao, J., Wang, D., Fan, M.*, Highly sensitive SERS detection of residual nitrofurantoin and 1-amino-hydantoin in aquatic products and feeds, Luminescence 2022, 37 (1), 82-88.. (IF=2.464, JCR Q4 in biochemistry)

2021年

60. Liu, W.; Zhou, S.; Liu, J.; Zhao, X.; Feng, Z.; Wang, D.; Gong, Z.; Fan, M.*, Quantitative detection of 6-thioguanine in body fluids based on a free-standing liquid membrane SERS substrate, Anal and Bioanal Chem 2021. (IF=4.142, JCR Q1 in analytical chemistry)

59. Fan, W.; Yang, S.; Gao, W.; Wang, D.; Fan, M.*, Highly sensitive bromide aided SERS detection of furazolidone and 3-amino-2-oxazolidinone residual in aquaculture products, Microchem. J. 2021, 169, 106532. (IF=3.206, JCR Q1 in analytical chemistry)

58. Liu, J.;  Liu, W.;  Zhou, S.;  Wang, D*; Gong, Z.; Fan, M., Free-Standing Membrane Liquid-State Platform for SERS-Based Determination of Norfloxacin in Environmental Samples, J Anal and Testing 2021.5:217–224 (2021)

57. Cheng, H.; Yang, S.-W.; Wang, D.-M.; Huang, B.; Fan, M.*; Zhang, L.-Y.; Xu, T.; Yang, G.-C., Study on the Photolysis Route of Nano 2,2ʹ,4,4ʹ,6,6ʹ–Hexanitrostillbene by Vibrational Spectroscopy, J Anal and Testing 2021.5:197–202 

56. Liu, J.;  Liu, W.;  Huang, Y.;  Zhao, X.; Feng, Z.*; Wang, D.; Gong, Z.;   Fan, M.*, Self-supporting liquid film as reproducible SERS platform for therapeutic drug monitoring of berberine hydrochloride in human urine, Microchem J, 2021.165:106122 (IF=3.206, JCR Q1 in analytical chemistry)

2020年

55. Jiang, X.; Liu, W.; Luo, B.; Liu, X.; Huang, Y.; Wang, D.;  Fan, M.*; Gong, Z.*, Copper foam in situ loaded with precious metal nanoparticles as transmission SEIRAS substrate for rapid detection of dithiocarbamate pesticides. Anal Methods 2020, 12 (28), 3600-3607.

54. 刘雯; 黄雨婷; 刘静; 晁生茂; 范美坤, 高重现性自支撑液膜SERS基底及其在定量分析中的应用. 光谱学与光谱分析 2020, 40 (S1), 153-154.

53. 唐灿; 黄兵; 刘柳; 范美坤; 周阳, 纳米HNS、TATB及LLM-105的RAW264.7巨噬细胞毒性及其机制. 含能材料 2020, 28 (8), 792.

52. Fan, W.;  Yang, S.;  Zhang, Y.;  Huang, B.;  Gong, Z.;  Wang, D.; Fan, M.*, Multifunctional Flexible SERS Sensor on a Fixate Gel Pad: Capturing, Derivation, and Selective Picogram Indirect Detection of Explosive 2,2′,4,4′,6,6′-Hexanitrostilbene, ACS Sensors, 2020, 5, 2933-2939.(IF=7.711, JCR Q1 in analytical chemistry)

51. Liu, Wen; Huang, Yuting; liu, jing; chao, shengmao; Liu, Xuke; wang, dongmei; Gong, Zhengjun; Li, Chun Mei; Fan, Meikun*; Huang, Cheng Zhi*, Self-Healing 3D Liquid Free-Standing Plasmonic Nanoparticle Membrane for Reproducible Surface-Enhanced Raman Spectroscopy Sensing, ACS Appl. Nano Mater. 2020, 3, 10, 10014–10021. (IF=5.097)

50. Yuting Huang, Wen Liu, Zhengjun Gong, Wei Wu, Meikun Fan*, Dongmei Wang*, and Alexandre G. Brolo*, Detection of Buried Explosives Using a Surface-Enhanced Raman Scattering (SERS) Substrate Tailored for Miniaturized Spectrometers, ACS Sensors, 2020, 5, 9, 2933-2939. (IF=7.333, JCR Q1 in analytical chemistry)

49. Yang S., Fan W., Cheng H., Gong Z, Wang D., Fan M.*, Huang B.*, A dual functional cotton swab sensor for rapid onsite naked-eye sensing of nitroaromatic explosives on surfaces, Microchemical Journal, 159（2020）105398. (IF=3.206, JCR Q1 in analytical chemistry)

48. Liu, W., Huang Y., Liu J., Chao S., Wang, D., Gong, Z.,Fan, M.* , Unsupported Liquid-state Platform for SERS-based Determination of Triazophos, Microchimica Acata,187, 502 (2020). (IF=6.232, JCR Q1 in analytical chemistry)

47. Yang, S., Fan, W., Cheng, H., Gong, Z., Wang, D., Fan, M.*, and Huang, B.*, From children's toy to versatile sensor: one-step doping of Play-Doh with primary amino group for explosive detection both on surfaces and in solution, Analytica Chimica Acta, 2020, 1128, 193-202. (IF=5.977, JCR Q1 in analytical chemistry)

46. Jiang, S., Tang, C., Gong, Z., Zhang, Z., Wang D.*, and Fan, M.*, Facile preparation of chitosan coated silver nanoparticles embedded cotton fabric for point-of-use water disinfection, Materials Letters, 2020, 277, 128256. (IF=3.204, JCR Q2 in Materials Science)

45. Sun, J., L. Gong, W. Wang, Z. Gong, D. Wang* and M. Fan*. Surface-enhanced Raman spectroscopy for on-site analysis: A review of recent developments. Luminescence, 2020, 1-13. (IF=1.691, JCR Q4 in biochemistry)

44. Liao Liu, Jiannan Chen,* Wuhuan Zhang, Meikun Fan,* Zhengjun Gong, Jianqiang Zhang,  Graphene oxide/polydimethylsiloxane composite sponge for removing Pb(ii) from water, RSC Adv., 2020,10, 22492-22499. (IF=3.049, JCR Q2 in chemistry multidisciplinary)

43. Yuting Huang, Dongmei Wang, Wen Liu, Lu Zheng, Yixu Wang, Xuke Liu,  Meikun Fan*, Zhengjun Gong*, Rapid Screening of Rhodamine B in Food by Hydrogel Solid-Phase Extraction Coupled with Direct Fluorescence Detection, Food Chemistry, 2020, 316, 126378. (IF=6.306, JCR Q1 in applied chemistry)

42.  Wanli Fan, Shiwei Yang, Dongmei Wang*, Zhengjun Gong, Meikun Fan*,Screening for malachite green contamination on live fish skin with chewing gum based viscoelastic SERS sensor, Journal of Food and Drug Analysis, 2020, 28, 37-44. (IF=4.176, JCR Q1 in food science)

41. Yuting Huang, Wen Liu, Dongmei Wang*, Zhengjun Gong, Meikun Fan*, Evaluation of the Intrinsic pH Sensing Performance of Surface-enhanced Raman Scattering pH Probes, Microchemical Journal, Volume 154, May 2020, Article 104565. (IF=3.206, JCR Q1 in analytical chemistry)

40. Wenjun Wang,  Zhengjun Gong*, Shiwei Yang, Tingting Xiong, Dongmei Wang, Meikun Fan,* Fluorescent and visual detection of norfloxacin in aqueous solutions with a molecularly imprinted polymer coated paper sensor, Talanta, 2020, 120435 (IF=4.916, JCR Q1 in analytical chemistry) 

39.Xuke Liu, Keru Lu, Wen Liu, Zhilin Li, Mansing Wong, Dongmei Wang, Zhengjun Gong*, Meikun Fan,* Multi-wavelength UV imaging detection system applied for varying environmental conditions: Detection of SO2 as an example, Microchemical Journal, Volume 153, March 2020, Article 104395. (IF=3.206, JCR Q1 in analytical chemistry)

38.Meikun Fan, Gustavo Andrade, Alexandre G. Brolo* A review on recent advances in the applications of surface-enhanced Raman scattering in analytical chemistry, Analytica Chimica Acta, 2020,1097,1-29 (Invited Review, IF=5.977, JCR Q1 in analytical chemistry，高被引论文)

2019年

37.Qiling Zhang, Wen Liu, Zhengjun Gong*, Wenjun Wang，Dongmei Wang, Xinchen Jiang, Lu Zheng, Shiwei Yang, Meikun Fan,* Silver nanoparticles on copper foam as substrate for full range mid-infrared surface enhanced infrared absorption spectroscopy in transmission configuration, Microchemical Journal, 2019, 151, 104252. (IF=3.206, JCR Q1 in analytical chemistry)

36. J Sun; L Gong; Z Gong; D Wang; X Yin, M Fan*, Facile fabrication of large-area and cost-effective PDMS-SERS substrate by sandpaper template-assisted lithography, Analytical Methods, 2019, 38, 4917-4922. (IF=2.073, JCR Q2 in spectroscopy)

35. Shiwei Yang , Wanli Fan , Dongmei Wang , Zhengjun Gong and Meikun Fan*, Fluorescence analysis of cobalt(II) in water with β-cyclodextrins modified Mn-doped ZnS quantum dots, Analytical Methods, 2019, 11, 3829 - 3836. (IF=2.073, JCR Q2 in spectroscopy)

34. Wang C., Wong K.W., Wang Q., Zhou Y., Tang C.*, Fan M.*, Mei J., Lau W. M., Silver-nanoparticles-loaded chitosan foam as a flexible SERS substrate for active collecting analytes from both solid surface and solution, Talanta, 2019, 191, 241-247. (IF=4.244, JCR Q1 in analytical chemistry)

33. X Gong, M Tang, Z Gong, Z Qiu, D Wang, M Fan*, Screening pesticide residues on fruit peels using portable Raman spectrometer combined with adhesive tape sampling, Food Chemistry, 2019, 295, 254-258. (IF=6.306, JCR Q1 in applied chemistry)(文章第一作者为我校本科毕业生(现南开大学直博)，本文为其毕业设计整理而成)

2018年

32.Fan M.*, Gong L., Sun J., Wang D., Gong Z.*, Killing two birds with one stone: coating Ag NPs embedded filter paper with chitosan for better and durable point-of-use water disinfection, ACS Applied Materials & Interfaces, 2018, 10 (44), 38239-38245. (IF=8.456, JCR Q1 in materials science)

31. Yang S., Fan W., Xiong T., Wang D., Qin K., Fan M.*, Gong Z.*, Decision table in Rough Set as a new chemometric approach for synthesis optimization: Mn-doped ZnS quantum dots as the example, Chemometrics and Intelligent Laboratory Systems, 2018, 182, 124-130. (IF=2.701, JCR Q2 in analytical chemistry)

30. Xiang X., Wang, Z., Xie F., Fan M.*, Sun X.*, Ammonia synthesis from electrocatalytic N2 reduction under ambient conditions by Fe2O3 nanorod, CHEMCATCHEM, 2018,10(20),4530-4535. (IF=4.674, JCR Q1 in physical chemistry)

29. Y. Wang, Y. Liu, W. Liu, W. Tang, L. Shen*, Z. Li, M Fan,* Quantification of combined color and shade changes in colorimetry and image analysis: water pH measurement as an example, Analytical Methods, 10 (2018) 3059-3065. (IF=2.073, JCR Q2 in spectroscopy)

28. J. Sun, L. Gong, Y.T. Lu, D.M. Wang, Z.J. Gong, M Fan,* Dual functional PDMS sponge SERS substrate for the on-site detection of pesticides both on fruit surfaces and in juice, Analyst, 143 (2018) 2689-2695. (IF=3.864, JCR Q1 in analytical chemistry)

27. M Fan,* L Gong, Y Huang, D Wang, Z Gong,* Facile preparation of silver nanoparticle decorated chitosan cryogels for point-of-use water disinfection, Science of The Total Environment, 613 (2018) 1317-1323. (IF=4.61, JCR Q1 in environmental science)

2017年

26.J Lv, Z Gong, Z He, J Yang,Y Chen, C Tang,* Y Liu, M Fan,*W-M Lau, 3D printing of a mechanically durable superhydrophobic porous membrane for oil–water separation, J. Mater. Chem. A, 5(2017), 12435-12444. (IF=9.931, JCR Q1 in physical chemistry)

25. L Huo, X Yang,* Z Liu, X Tian, T Qi, X Wang, K Yu, J Sun, M Fan,*Modulation of potential barrier heights in Co3O4/SnO2heterojunctions for highly H2-selective sensors, Sensors and Actuators B: Chemical, 244 (2017), 694-700. (IF=5.667, JCR Q1 in analytical chemistry)

2016年

24. Z Gong, C Wang, S Pu, C Wang, F Cheng, M Fan,* Rapid and direct detection of illicit dyes on tainted fruit peel using PVA hydrogel surface enhanced Raman scattering substrate, Analytical Methods, 2016,8, 4816-4820. 影响因子2.07

2015年

23. Meikun Fan,* SERS Nanoprobes as Cancer Theranostics, in Nanomaterials for Tumor Targeting Theranostics: A Proactive Clinical Perspective, Mingqian Tan and Aiguo Wu (Eds.), World Scientific Publishing, Singapore, 2015, ISBN: 978-9814635417 (专著)

22. M Fan,* F Cheng,C Wang, Z Gong, C Tang, C Man, AG Brolo, SERS Optrode as a “fishing rod” to direct pre-concentrate analytes from superhydrophobic surfaces, Chemical Communications, 51 (2015), 1965-1968. 影响因子6.83.

2014年

21. Z Gong, H Du, F Cheng, C Wang, C Wang, M Fan,* Fabrication of SERS Q-tip for direct swab detection of trace explosives in fingerprints, ACS Applied Materials & Interfaces, 6(2014),21931-21937.影响因子8.09. Cited 21 times.

20. F Cheng, H Xu,  C Wang,  Z Gong,  C Tang,  M Fan,* Surface enhanced Raman scattering fiber optic sensor as ion selective optrode: the example of Cd2+ detection, RSC Advances, 4 (2014), 64683-64687. 影响因子3.708

19. M Fan,* Z Zhang, J Hu, F Cheng, C Wang, C Tang, J Lin, AG Brolo, H Zhan,* Ag decorated sandpaper as flexible SERS substrate for direct swabbing sampling, Materials Letters, 133(2014), 57-59. 影响因子2.269. Cited 15 times

18. Z Gong, C Wang, C Wang, C Tang, F Cheng, H Du, M Fan,* AG Brolo,* A silver nanoparticle embedded hydrogel as a substrate for surface contamination analysis by surface-enhanced Raman scattering, Analyst 139 (2014), 5283-5289. 影响因子4.11. Cited 7 times

17. C Wang, F Cheng, Y Wang, Z Gong, M Fan,* J Hu, Single point calibration for semi-quantitative screening based on an internal reference in thin layer chromatography-SERS: the case of Rhodamine B in chili oil, Analytical Methods 6 (2014), 7218-7223. 影响因子1.94

16. CY Tang,* GC Long, X Hu, KW Wong, WM Lau, M Fan, J Mei, T  Xu, B Wang, Conductive polymer nanocomposites with hierarchical multi-scale structures via self-assembly of carbon-nanotubes on graphene on polymer-microspheres, Nanoscale, 2014,6, 7877-7888. 影响因子6.739

2013年

15. CP Shaw, M Fan,* C Lane, G Barry, AI Jirasek, AG Brolo, Statistical Correlation Between SERS Intensity and Nanoparticle Cluster Size, The Journal of Physical Chemistry C 117 (2013), 16596-16605. 影响因子4.835. Cited 3 times.

14. C Yao, F Cheng, C Wang, Y Wang, X Guo, Z Gong, M Fan,* Z Zhang, Separation, identification and fast determination of organophosphate pesticide methidathion in tea leaves by thin layer chromatography–surface-enhanced Raman scattering, Analytical Methods 5 (2013), 5560-5564. 影响因子1.94. Cited 11 times.

13. Fan, M.K., Lai, Feng-Ju; Chou, Hung-Lung; et al.，Surface-enhanced Raman scattering (SERS) from Au:Ag bimetallic nanoparticles: the effect of the molecular probe，Chemical Science, 4(2013): 509-515. 影响因子9.2. Cited 44 times.

2012年

12. Fan, M. K., Wang, P. H.; Escobedo, C.; et al.，Surface-enhanced Raman scattering (SERS) optrodes for multiplexed on-chip sensing of nile blue A and oxazine 720，Lab on a Chip, 12 (2012): 1554-1560. 影响因子6.11. Cited 22 times.

2011年

11. Fan, M. K., Andrade, G. F. S.; Brolo, A. G.，A review on the fabrication of substrates for surface enhanced Raman spectroscopy and their applications in analytical chemistry，Analytica Chimica Acta, 693 (2011): 7-25. 影响因子4.517. Cited 362 times, among the Highly Cited Papers in Web of Knowledge database.

10. Fan, M. K., Marechal, M.; Finn, A.; et al.，Layer-by-Layer Characterization of a Model Biofuel Cell Anode by (in Situ) Vibrational Spectroscopy，Journal of Physical Chemistry C, 115(2011): 310-316. 影响因子4.835. Cited 4 times.

2010年

9. Fan, M. K.; Thompson, M.; Andrade, M. L.; et al.，Silver Nanoparticles on a Plastic Platform for Localized Surface Plasmon Resonance Biosensing，Analytical Chemistry 82 (2010): 6350-6352 影响因子5.825. Cited 62 times.

8. Andrade, G. F. S.; Fan, M. K.; *Brolo, A. G.， Multilayer silver nanoparticles-modified optical fiber tip for high performance SERS remote sensing，Biosensors & Bioelectronics 25 (2010): 2270-2275 影响因子6.451. Cited 72 times.

2009年

7. Fan, M.; Brolo, A. G.，Silver nanoparticles self assembly as SERS substrates with near single molecule detection limit，Physical Chemistry Chemical Physics, 11(2009): 7381-7389 影响因子4.198. Cited 111 times.

2008年

6. Fan, M. K.; Brolo, A. G.，Self-assembled Au nanoparticles as substrates for surface-enhanced vibrational spectroscopy: Optimization and electrochemical stability，Chemphyschem 9(2008): 1899-1907. 影响因子3.360. Cited 29 times.

2005年

5. 陈宇春; 范美坤*; 肖光; 宿艳; 潘玉珍，一种新型液-液界面全内反射分光光度测定装置。光谱实验室 22(2005):369-371

2004年

4. 肖光; 范美坤; 韩梅; 崔丽钧; 维生素C片剂的紫外分光光度法测定。光谱实验室 21(2004):947-949

2002年

3. CZ Huang, MK Fan, YF Li, Fluorescence microscopic quantification of DNA with α, β, γ, δ-tetrakis [4-(trimethylammonium) phenyl] porphine by a ring-like deposition technique, Analytica Chimica Acta 466 (2002), 193-200

2. MK Fan, CZ Huang, YF Li, Fluorescent microscopic determination of cadmium in water samples with the self-ordered ring of α, β, γ, δ-tetra (5-sulfophenyl) porphine formed on the solid support of glass slides, Analytica Chimica Acta 453 (2002), 97-104

1. CZ Huang, MK Fan, Y Fang Li, Determination of trace amount of aluminum in water samples by a fluorescent microscopic self-ordered ring technique, Analytical Letters 35 (2002), 2565-2576

专利：

1. 范美坤，胡建明等，一种表面增强拉曼基底及其制备方法，中国发明专利, 专利号ZL201210189572.x。

2. 范美坤，胡建明等，一种基于表面增强拉曼检测超痕量样品的方法和装置，中国发明专利，专利号ZL201210436192.1。

3. 范美坤，胡建明等，便携式自适应定位拉曼光谱仪，实用新型专利， 专利号ZL201220270485.2。

4. 范美坤，龚正君，何雨希等，一种纳米粒子计数方法，中国发明专利，专利号ZL 201610036052.3。

5. 范美坤，龚正君，何雨希等，一种液体中细菌的计数方法，发明专利，专利号ZL 201610036039.8。

6. 范美坤，龚正君，龚林等，净水元件、净水元件的制备方法及净水器，发明专利，申请号201610998802.5。

7. 龚正君，范美坤，张琦苓等，基于三维结构的红外表面增强基底及其制备方法，发明专利，申请号201611026202.9。

8. 范美坤，龚正君，孙姬，一种基于PDMS海绵的表面增强拉曼光谱基底及其制备方法，中国发明专利，申请号201710377628.7。

9. 范美坤，龚正君，樊碗丽等，表面增强拉曼光谱基底及其制备方法，中国发明专利，申请号201710440827.8。

10. 范美坤，龚正君，龚林等，具有杀菌功能的过滤材料及其制备方法，中国发明专利，专利号201710549071。

11. 范美坤，刘雯，黄雨婷等，高重现性表面增强拉曼散射的基底材料及其使用方法，中国发明专利，申请号：201910333986.7。

12. 龚正君，范美坤，江欣承，王东梅，基于置换反应的红外透射基底的制备方法，中国发明专利，申请号：201910155784.8。

13. 范美坤，黄雨婷，刘雯，龚正君，王东梅，具有内在拉曼光子导向能力的SERS基底及其制备方法，中国发明专利，申请号：201910755299.4。

14. 唐昶宇，范美坤，王东梅，龚正君，江水苹，晁生茂等，一种超疏水杀菌材料及其制备方法，中国发明专利，申请号：202010879472.4。

15. 范美坤，黄雨婷，王雪擎，慎利，陈俊敏，李志林，污水溯源方法，中国发明专利，申请号：202010024827.1。

16. 刘了，范美坤，张建强，龚正君，氧化石墨烯海绵材料及其制备和使用方法，中国发明专利，申请号：201910428084.1。

会议报告：

26. 范美坤，面向环境分析的SERS基底研究：从双功能到高重现性分析（邀请报告），第二十一届全国光散射学术会议（在线），2021.12.27.

25. Meikun Fan，3D free standing liquid membrane SER substrate for accurae quantification analysis (also serve as session moderator), Pacifichem 2021 (online), 2021.12.18

24. 范美坤，基于多维度表面增强拉曼光谱指纹的细菌识别技术, 第三届全国环境分析化学会议，贵阳，2021.10.18.

23. 范美坤，表面增强拉曼光谱技术在现场快速分析中的应用（邀请报告），第二届全国光谱大会，北京，2021.6.16.

22. 范美坤，分子光谱分析技术在食品安全检测中的应用（邀请报告），中国工程院第320场中国工程科技论坛暨第七届中国食品安全高峰论坛，广州，2020.11.29.

21. 范美坤，On-site SERS analysis: from fast qualitative screening to convenient quantitative detection（邀请报告），21届全国分子光谱大会，成都，2020.10.31.

20. 范美坤，Surface Enhanced Raman Spectroscopy (SERS) in Environmental Study: Two Examples，第三届中国化学快报青年环境化学家论坛，广州，2020.10.23.

19. 范美坤，表面增强拉曼光谱技术在食品安全快速检测中的应用（邀请报告），ICS2020（第九届光谱网络会议），仪器信息网，2020.05.27.

18. M.K. Fan, Quantitative SERS, The plasmonic NPs suspension formed self-healing 3D liquid free-standing membrane platform approach, 21st International Symposium on Advances in Extraction Technologies, Guangzhou, 2019.11

17. M.K. Fan,The Development of Dual Functional Flexible SERS Substrates and Their Applications in Food Safety and Homeland Security, 第十届全国环境化学大会，天津，2019.08

16. M.K. Fan, Surprising Improvement on SERS Reproducibility in MNPs-Suspension-Formed 3D Free-standing Membrane，102nd Canadian Chemistry Conference and Exibition, Quebec, Canada, 2019.06

15. M.K. Fan, Developing shape adaptable surface enhanced Raman scattering (SERS) substrates for surface contamination analysis, Pacifichem 2015, Honolulu, U.S.A., 2015

14. Invited talk, Developing shape adaptable SERS substrate for surface contamination analysis, Southwest China Regional Workshop for Analytical Chemistry, Chengdu, China, 2014

13. Invited talk, Application of surface enhanced Raman scattering technique in environmental monitoring and food quality assurance, West China Normal University, Nanchong, China, 2013.

12. Invited talk, When surface enhanced Raman scattering meets homeland security and food quality assurance, Dalian Polytechnic University, Dalian, China, 2012.

11. M. K. Fan,* et al, Green route for fabrication of superhydrophobic surface enhanced Raman scattering dual functional platform by ultrasound assisted electroless deposition of silver on sandpaper (oral), 97th Canadian Chemistry Conference and Exhibition, Vancouver, Canada, 2014.

10. M. K. Fan,* et al, Sub-attomolar sensitivity through directed pre-concentration on super-hydrophobic surface using an SERS optrode (poster), 2nd international conference on frontiers of plasmonics, Chengdu, China, 2012.

9. M. K. Fan, A. G. Brolo, Layer-by-layer fabrication of SERS optrode and its application in bio-analysis (oral), 11th Asian conference for analytical science, Nanjing, China, 2011.

8. M. K. Fan, A. G. Brolo, Silver nanoparticles on a plastic platforms for bio-sensing (oral), 93rd Canadian Chemistry Conference and Exhibition, Toronto, Canada, 2010

7. M. K. Fan,  G. F. S. Andrade, A. G. Brolo, Multilayer Silver Nanoparticles Modified Optical Fiber Tip for High Performance SERS Remote Sensing (oral), 217th Electrochemical Society Meeting, Vancouver, 2010

6. M. K. Fan, M. Thompson, M. L. Andrade, A. G. Brolo, Localized surface plasmon (LSPR)-based sensor on plastics: metallic NPs on polyethylene terephthalate (PET) film as versatile platforms for bio-sensing (poster), Second BiopSys All Network Meeting ( ANM-2), Toronto, 2009

5. G. F. S. Andrade, M. K. Fan, J. G. Hayashi, A. M. Brito-Silva, M. M. Rahman, A. G. Brolo, Plasmonic modification of optical fibres for remote diagnosis: devices development (poster), Second BiopSys All Network Meeting ( ANM-2), Toronto, 2009

4. M. K. Fan, A. G. Brolo, H.-L. Chou, F.-J. Lai, W.-T. Lu, B.-J. Hwang, Probe specific surface enhanced Raman scattering (SERS) in Au:Ag nanoparticle alloys(oral), 92nd Canadian Chemistry Conference and Exhibition, Hamilton, Canada, 2009

3. M. K. Fan, A. G. Brolo, Self-assembly Ag NPs as SERS substrate with near single molecule sensitivity and low spatial variation (poster), the 13th Annual Meeting of the Pacific Center for Advanced Materials and Microstructures (PCAMM), Victoria, Canada, 2008

2. M. K. Fan, A. Finn, M. Maréchal, D. Harrington, A. G. Brolo, New SERS substrate development and its application in Biofuel cell research (oral), 91st Canadian Chemistry Conference and Exhibition, Edmonton, Canada, 2008

1. M. K. Fan, A. Finn, M. Maréchal, D. Harrington, A. G. Brolo, Characterizing a Biofuel Cell Anode by Surface-Enhanced Raman Scattering (SERS) (poster), the 58th Annual Meeting of the International Society of Electrochemistry, Banff, Canada, 2007

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In brief

  课题组目前主要有四个研究大方向/There are currently four research streams carried out in the FAN group.  

1. 基于贵金属纳米材料的环境和生物医学分析化学，特别是包括食品和公共安全的现场快速分析化学/Coinage metallic nanomaterials based environmental and biomedical analytical chemistry;

2. 绿色化学，特别是基于纳米材料的分散式饮用水处理材料研究/Nanomaterials based point of use pollution control and water disinfection;

3. 大气颗粒污染物界面化学研究/Heterogeneous chemical processes on particulate matter pollutants;and

4. 基于COMS相机成像环境分析化学/COMS camera based analytical chemistry.

Projects (国家及省部级项目，不含横向课题) 

[13] General Grant (国家自然科学基金面上项目) (NO.22076153, 2021-2024, RMB 630,000):The fabrication of highly reproducible free standing liquid membrane SERS substrate and its application in environmental analysis (高重现性自支撑液膜SERS基底及其在现场环境分析中的应用,) National Natural Science Foundation of China.

[12] Young scholar program (国家自然科学青年基金项目) (NO. 22006121, 2021-2023,RMB 240,000)：基于回归反光SERS基底的土壤气典型有机污染物原位检测方法研究, National Natural Science Foundation of China (PI: Dr. Wang).

[11] Reginal Collaboration R&D Program of Sichuan Province (四川省区域创新合作项目 ) (NO. 2020YFQ0026, 2020-2022, RMB 400,000)，基于物联网的城镇分散生活垃圾清洁储存与大数据统筹转运模式研究示范. Ministry of Science and Technology of Sichuan Province.

[10] International R&D Program of Sichuan Province (四川省国际科技创新合作/港澳台科技创新合作项目)(NO. 2020YFH0048, 2020-2021, RMB 200,000) SERS spectra based machine learning for polluted water sourcing in industral zone. Ministry of Science and Technology of Sichuan Province （基于SERS光谱指纹深度学习的工业园区水体污染物溯源关键技术研究），(PI: Dr. Shen).

[9] Key R&D Program of Sichuan Province (四川省基金重点项目) (NO. 2018GZ0400, 2018-2019, RMB 200,000) Nanomaterials based point-of-use water disinfectants for emergency relief. Ministry of Science and Technology of Sichuan Province (PI: Dr. Wang).

[8] General Grant (国家自然科学基金面上项目) (NO. 21777131, 2018-2021, RMB 670,000): Solid-phase microextraction with fluoresence detection for surface contamination analysis, National Natural Science Foundation of China (PI: Prof. Gong).

[7] General Grant (国家自然科学基金面上项目) (NO. 21677117, 2017-2020, RMB 680, 000): The development of shape conformable polymer gel surface enhanced Raman scattering substrate and its application in surface contamination analysis. National Natural Science Foundation of China.

[6] Key R&D Program of Sichuan Province (四川省基金重点项目) (NO. 2017GZ0388, 2017, RMB 200, 000 ): The development of portable surface enhanced Raman spectrometer for the detection of pesticide and illicit dye residues on agricultural products. Ministry of Science and Technology of Sichuan Province.

[5] Fundamental Research Funds for the National Universities of China (No. 2682017CX085, 2017, RMB 100, 000): The development of silver nanoparticle doped polymer cryogels for point of use water disinfection applications, Ministry of Education, China.

[4] Young scholar program (国家自然科学青年基金项目) (NO. 21307099, 2014-2016,RMB 250,000)：Fast determination of bacteria in water environment with surface enhanced infrared absorption method, National Natural Science Foundation of China (PI: Prof. Gong).

[3] Fundamental Research Funds for the National Universities of China (No. 2682014RC06, 2014, RMB 200, 000): Detection method for fast onsite screening of illicit drugs, Ministry of Education, China.

[2] General Grant (国家自然科学基金面上项目)  (No. 21277131, 2013-2016, RMB 800, 000): The development and environmental applications of an analytical device based on surface enhanced Raman scattering (SERS) optrode induced pre-concentration on superhydrophobic surfaces, National Natural Science Foundation of China.

[1]Young Scientist Grant (国家自然科学青年基金项目) (No. 21105092, 2012-2014, RMB 250, 000): The development of surface modified SERS Optrode for environmental monitoring application, National Natural Science Foundation of China.