Faculty Profile

Note to international students:

I do accept international student (from MSc to PhD level). However, DO NOT contact me if you did not go through my C.V. In addition, all international students MUST submit a RESEARCH PROPOSAL (3-5 pages) based on my research interests and your background BEFORE asking a supporting letter. 

Research Interests   

1. Surface Enhanced Vibrational Spectroscopy

     Surface enhanced vibrational spectroscopy (SEVS), namely surface enhanced Raman scattering (SERS) and surface enhanced infrared absorption spectroscopy (SEIAS), as its name indicates, is a molecular vibrational spectroscopy enhanced by certain coinage metallic nanomaterials, such as gold, silver, and copper. There are many advantages in applying SEVS for chemical analysis. For example, SERS is known to be very sensitive, single molecule analysis has been widely reported in literature by the using of SERS. On top of sensitivity, SEVS also provides the fingerprint-like information of molecules, which helps the identification of analyte. In addition, the instruments, both Raman and infrared spectrometers, are capable of miniaturizing. Hence, researchers all around the world are working on this technique, developing methods for many applications, including biomedical, homeland security, and many other fields.

     We have specifically focused on the application of SEVS in environmental monitoring. We have 4 grants from national natural science foundation of China supporting the research in this direction, with a total budget of 2.1 million CNY.

     In the past, we tried to develop SERS Optrode, or SERS optical fiber sensor, for remote sensing. Later, we combine the Optrode with superhydrophobic surface to form analytical device for trace sample analysis. The SERS Optrode was used as the fishing hook to preconcentrate analyte on the surface of a superhydrophobic material. Recently, we shift our interest on surface contaminants, such as pesticides on fruit surfaces, and explosives on luggage. We proposed a shape adaptable hydrogel SERS substrate for this specific application.

     We are also working on SEIAS for bacteria sensing.

2. Imaging Based Environmental Monitoring

     COMS image sensor has been widely utilized in smartphone as well as DSLR cameras as the image acquiring device. It can also be used in analytical chemistry, for the acquiring of optical signal. Currently, the smartphone based sensing is mostly for point analysis, it is still difficult to acquire large amount of data simultaneously. On the other hand, hyperspectral imaging has become one of the main stream remote sensing technique in environmental survey. However, it still lacks the capability of detect accurate chemical pollutants information. We want to bridge the two techniques to provide instant and high throughput information of local pollution.

3. Point of Use pollution control materials

     This theme we aim to develop point of use water disinfection materials. In other words, we intend to develop novel materials to help people in resource limited countries and situations get clean and safe water.

4. Localized Surface Plasmon Resonance Analysis

     Point of care diagnostics will be one of the most important move in future healthcare development. When combined with internet, all data related to a patient can be collected instantly and transferred to a doctor. In such a way a care can be quickly provided to the patient. This is called modern telemedicine. In this theme we intend to develop sensors that can detect analytes that is clinically important, based on modern nano-technology.

Selected publications and manuscripts

 

2020年

43. Yuting Huang, Dongmei Wang, Wen Liu, Lu Zheng, Yixu Wang, Xuke Liu,  Meikun Fan*, Zhengjun Gong*, Rapid Screening of Rhodamine B in Food by Hydrogel Solid-Phase Extraction Coupled with Direct Fluorescence Detection, Food Chemistry, accepted. (IF=4.946, JCR Q1 in applied chemistry) 

42.  Wanli Fan, Shiwei Yang, Dongmei Wang*, Zhengjun Gong, Meikun Fan*,Screening for malachite green contamination on live fish skin with chewing gum based viscoelastic SERS sensor, Journal of Food and Drug Analysis, accepted. (IF=4.176, JCR Q1 in food science)

41. Yuting Huang, Wen Liu, Dongmei Wang*, Zhengjun Gong, Meikun Fan*, Evaluation of the Intrinsic pH Sensing Performance of Surface-enhanced Raman Scattering pH Probes, Microchemical Journal, Volume 154, May 2020, Article 104565. (IF=3.206, JCR Q1 in analytical chemistry)

40. Wenjun Wang,  Zhengjun Gong*, Shiwei Yang, Tingting Xiong, Dongmei Wang, Meikun Fan,* Fluorescent and visual detection of norfloxacin in aqueous solutions with a molecularly imprinted polymer coated paper sensor, Talanta, 2020, 120435 (IF=4.916, JCR Q1 in analytical chemistry) 

39.Xuke Liu, Keru Lu, Wen Liu, Zhilin Li, Mansing Wong, Dongmei Wang, Zhengjun Gong*, Meikun Fan,* Multi-wavelength UV imaging detection system applied for varying environmental conditions: Detection of SO2 as an example, Microchemical Journal, Volume 153, March 2020, Article 104395. (IF=3.206, JCR Q1 in analytical chemistry)

38.Meikun Fan, Gustavo Andrade, Alexandre G. Brolo* A review on recent advances in the applications of surface-enhanced Raman scattering in analytical chemistry, Analytica Chimica Acta, Volume 1097, 8 February 2020, Pages 1-29 (Invited Review, IF=5.256, JCR Q1 in analytical chemistry))

 

2019年

37.Qiling Zhang, Wen Liu, Zhengjun Gong*, Wenjun Wang，Dongmei Wang, Xinchen Jiang, Lu Zheng, Shiwei Yang, Meikun Fan,* Silver nanoparticles on copper foam as substrate for full range mid-infrared surface enhanced infrared absorption spectroscopy in transmission configuration, Microchemical Journal, 2019, 151, 104252. (IF=3.206, JCR Q1 in analytical chemistry)

36. J Sun; L Gong; Z Gong; D Wang; X Yin, M Fan*, Facile fabrication of large-area and cost-effective PDMS-SERS substrate by sandpaper template-assisted lithography, Analytical Methods, 2019, 38, 4917-4922. (IF=2.073, JCR Q2 in spectroscopy)

35. Shiwei Yang , Wanli Fan , Dongmei Wang , Zhengjun Gong and Meikun Fan*, Fluorescence analysis of cobalt(II) in water with β-cyclodextrins modified Mn-doped ZnS quantum dots, Analytical Methods, 2019, 11, 3829 - 3836. (IF=2.073, JCR Q2 in spectroscopy)

34. Wang C., Wong K.W., Wang Q., Zhou Y., Tang C.*, Fan M.*, Mei J., Lau W. M., Silver-nanoparticles-loaded chitosan foam as a flexible SERS substrate for active collecting analytes from both solid surface and solution, Talanta, 2019, 191, 241-247. (IF=4.244, JCR Q1 in analytical chemistry)

33. X Gong, M Tang, Z Gong, Z Qiu, D Wang, M Fan*, Screening pesticide residues on fruit peels using portable Raman spectrometer combined with adhesive tape sampling, Food Chemistry, 2019, 295, 254-258. (IF=4.946, JCR Q1 in applied chemistry)(文章第一作者为我校本科毕业生(现南开大学直博)，本文为其毕业设计整理而成)

 

2018年

 

32.Fan M.*, Gong L., Sun J., Wang D., Gong Z.*, Killing two birds with one stone: coating Ag NPs embedded filter paper with chitosan for better and durable point-of-use water disinfection, ACS Applied Materials & Interfaces, 2018, 10 (44), 38239-38245. (IF=8.456, JCR Q1 in materials science)

31. Yang S., Fan W., Xiong T., Wang D., Qin K., Fan M.*, Gong Z.*, Decision table in Rough Set as a new chemometric approach for synthesis optimization: Mn-doped ZnS quantum dots as the example, Chemometrics and Intelligent Laboratory Systems, 2018, 182, 124-130. (IF=2.701, JCR Q2 in analytical chemistry)

30. Xiang X., Wang, Z., Xie F.,  Fan M.*, Sun X.*, Ammonia synthesis from electrocatalytic N2 reduction under ambient conditions by Fe2O3 nanorod, CHEMCATCHEM, doi: 10.1002/cctc.201801208. (IF=4.674, JCR Q1 in physical chemistry)

29. Y. Wang, Y. Liu, W. Liu, W. Tang, L. Shen*, Z. Li,  Fan M.*, Quantification of combined color and shade changes in colorimetry and image analysis: water pH measurement as an example, Analytical Methods, 10 (2018) 3059-3065. (IF=2.073, JCR Q2 in spectroscopy)

28. J. Sun, L. Gong, Y.T. Lu, D.M. Wang, Z.J. Gong,  Fan M.*, Dual functional PDMS sponge SERS substrate for the on-site detection of pesticides both on fruit surfaces and in juice, Analyst, 143 (2018) 2689-2695. (IF=3.864, JCR Q1 in analytical chemistry)

27.  Fan M.*, L Gong, Y Huang, D Wang, Z Gong,* Facile preparation of silver nanoparticle decorated chitosan cryogels for point-of-use water disinfection, Science of The Total Environment, 613 (2018) 1317-1323. (IF=4.61, JCR Q1 in environmental science)

 

2017年

 

26.J Lv, Z Gong, Z He, J Yang,Y Chen, C Tang,* Y Liu, M Fan,*W-M Lau, 3D printing of a mechanically durable superhydrophobic porous membrane for oil–water separation, J. Mater. Chem. A, 5(2017), 12435-12444. (IF=9.931, JCR Q1 in physical chemistry)

25. L Huo, X Yang,* Z Liu, X Tian, T Qi, X Wang, K Yu, J Sun, M Fan,*Modulation of potential barrier heights in Co3O4/SnO2heterojunctions for highly H2-selective sensors, Sensors and Actuators B: Chemical, 244 (2017), 694-700. (IF=5.667, JCR Q1 in analytical chemistry)

2016年

24. Z Gong, C Wang, S Pu, C Wang, F Cheng, M Fan,* Rapid and direct detection of illicit dyes on tainted fruit peel using PVA hydrogel surface enhanced Raman scattering substrate, Analytical Methods, 2016,8, 4816-4820. 影响因子2.07

2015年

23. Meikun Fan,* SERS Nanoprobes as Cancer Theranostics, in Nanomaterials for Tumor Targeting Theranostics: A Proactive Clinical Perspective, Mingqian Tan and Aiguo Wu (Eds.), World Scientific Publishing, Singapore, 2015, ISBN: 978-9814635417 (专著)

22. M Fan,* F Cheng,C Wang, Z Gong, C Tang, C Man, AG Brolo, SERS Optrode as a “fishing rod” to direct pre-concentrate analytes from superhydrophobic surfaces, Chemical Communications, 51 (2015), 1965-1968. 影响因子6.83.

2014年

21. Z Gong, H Du, F Cheng, C Wang, C Wang, M Fan,* Fabrication of SERS Q-tip for direct swab detection of trace explosives in fingerprints, ACS Applied Materials & Interfaces, 6(2014),21931-21937.影响因子8.09. Cited 21 times.

20. F Cheng, H Xu,  C Wang,  Z Gong,  C Tang,  M Fan,* Surface enhanced Raman scattering fiber optic sensor as ion selective optrode: the example of Cd2+ detection, RSC Advances, 4 (2014), 64683-64687. 影响因子3.708

19. M Fan,* Z Zhang, J Hu, F Cheng, C Wang, C Tang, J Lin, AG Brolo, H Zhan,* Ag decorated sandpaper as flexible SERS substrate for direct swabbing sampling, Materials Letters, 133(2014), 57-59. 影响因子2.269. Cited 15 times

18. Z Gong, C Wang, C Wang, C Tang, F Cheng, H Du, M Fan,* AG Brolo,* A silver nanoparticle embedded hydrogel as a substrate for surface contamination analysis by surface-enhanced Raman scattering, Analyst 139 (2014), 5283-5289. 影响因子4.11. Cited 7 times

17. C Wang, F Cheng, Y Wang, Z Gong, M Fan,* J Hu, Single point calibration for semi-quantitative screening based on an internal reference in thin layer chromatography-SERS: the case of Rhodamine B in chili oil, Analytical Methods 6 (2014), 7218-7223. 影响因子1.94

16. CY Tang,* GC Long, X Hu, KW Wong, WM Lau, M Fan, J Mei, T  Xu, B Wang, Conductive polymer nanocomposites with hierarchical multi-scale structures via self-assembly of carbon-nanotubes on graphene on polymer-microspheres, Nanoscale, 2014,6, 7877-7888. 影响因子6.739

2013年

15. CP Shaw, M Fan,* C Lane, G Barry, AI Jirasek, AG Brolo, Statistical Correlation Between SERS Intensity and Nanoparticle Cluster Size, The Journal of Physical Chemistry C 117 (2013), 16596-16605. 影响因子4.835. Cited 3 times.

14. C Yao, F Cheng, C Wang, Y Wang, X Guo, Z Gong, M Fan,* Z Zhang, Separation, identification and fast determination of organophosphate pesticide methidathion in tea leaves by thin layer chromatography–surface-enhanced Raman scattering, Analytical Methods 5 (2013), 5560-5564. 影响因子1.94. Cited 11 times.

13. Fan, M.K., *Lai, Feng-Ju; Chou, Hung-Lung; et al.，Surface-enhanced Raman scattering (SERS) from Au:Ag bimetallic nanoparticles: the effect of the molecular probe，Chemical Science, 4(2013): 509-515. 影响因子9.2. Cited 44 times.

2012年

12. Fan, M. K.,* Wang, P. H.; Escobedo, C.; et al.，Surface-enhanced Raman scattering (SERS) optrodes for multiplexed on-chip sensing of nile blue A and oxazine 720，Lab on a Chip, 12 (2012): 1554-1560. 影响因子6.11. Cited 22 times.

2011年

11. Fan, M. K.,* Andrade, G. F. S.; Brolo, A. G.，A review on the fabrication of substrates for surface enhanced Raman spectroscopy and their applications in analytical chemistry，Analytica Chimica Acta, 693 (2011): 7-25. 影响因子4.517. Cited 362 times, among the Highly Cited Papers in Web of Knowledge database.

10. Fan, M. K.,* Marechal, M.; Finn, A.; et al.，Layer-by-Layer Characterization of a Model Biofuel Cell Anode by (in Situ) Vibrational Spectroscopy，Journal of Physical Chemistry C, 115(2011): 310-316. 影响因子4.835. Cited 4 times.

2010年

9. Fan, M. K.; *Thompson, M.; Andrade, M. L.; et al.，Silver Nanoparticles on a Plastic Platform for Localized Surface Plasmon Resonance Biosensing，Analytical Chemistry 82 (2010): 6350-6352 影响因子5.825. Cited 62 times.

8. Andrade, G. F. S.; Fan, M. K.; *Brolo, A. G.， Multilayer silver nanoparticles-modified optical fiber tip for high performance SERS remote sensing，Biosensors & Bioelectronics 25 (2010): 2270-2275 影响因子6.451. Cited 72 times.

2009年

7. Fan, M.; *Brolo, A. G.，Silver nanoparticles self assembly as SERS substrates with near single molecule detection limit，Physical Chemistry Chemical Physics, 11(2009): 7381-7389 影响因子4.198. Cited 111 times.

2008年

6. Fan, M. K.; *Brolo, A. G.，Self-assembled Au nanoparticles as substrates for surface-enhanced vibrational spectroscopy: Optimization and electrochemical stability，Chemphyschem 9(2008): 1899-1907. 影响因子3.360. Cited 29 times.

2005年

5. 陈宇春; 范美坤*; 肖光; 宿艳; 潘玉珍，一种新型液-液界面全内反射分光光度测定装置。光谱实验室 22(2005):369-371

2004年

4. 肖光; 范美坤; 韩梅; 崔丽钧; 维生素C片剂的紫外分光光度法测定。光谱实验室 21(2004):947-949

2002年

3. CZ Huang, MK Fan, *YF Li, Fluorescence microscopic quantification of DNA with α, β, γ, δ-tetrakis [4-(trimethylammonium) phenyl] porphine by a ring-like deposition technique, Analytica Chimica Acta 466 (2002), 193-200

2. MK Fan, *CZ Huang, YF Li, Fluorescent microscopic determination of cadmium in water samples with the self-ordered ring of α, β, γ, δ-tetra (5-sulfophenyl) porphine formed on the solid support of glass slides, Analytica Chimica Acta 453 (2002), 97-104

1. CZ Huang, MK Fan, *Y Fang Li, Determination of trace amount of aluminum in water samples by a fluorescent microscopic self-ordered ring technique, Analytical Letters 35 (2002), 2565-2576

专利：

1. 范美坤，胡建明等，一种表面增强拉曼基底及其制备方法，中国发明专利, 专利号ZL201210189572.x。

2. 范美坤，胡建明等，一种基于表面增强拉曼检测超痕量样品的方法和装置，中国发明专利，专利号ZL201210436192.1。

3. 范美坤，胡建明等，便携式自适应定位拉曼光谱仪，实用新型专利， 专利号ZL201220270485.2。

4. 范美坤，龚正君，何雨希等，一种纳米粒子计数方法，中国发明专利，专利号ZL 201610036052.3。

5. 范美坤，龚正君，何雨希等，一种液体中细菌的计数方法，发明专利，专利号ZL 201610036039.8。

6. 范美坤，龚正君，龚林等，净水元件、净水元件的制备方法及净水器，发明专利，申请号201610998802.5。

7. 龚正君，范美坤，张琦苓等，基于三维结构的红外表面增强基底及其制备方法，发明专利，申请号201611026202.9。

8. 范美坤，龚正君，孙姬，一种基于PDMS海绵的表面增强拉曼光谱基底及其制备方法，中国发明专利，申请号201710377628.7。

9. 范美坤，龚正君，樊碗丽等，表面增强拉曼光谱基底及其制备方法，中国发明专利，申请号201710440827.8。

10. 范美坤，龚正君，龚林等，具有杀菌功能的过滤材料及其制备方法，中国发明专利，申请号201710549071.0。

11. 范美坤，刘雯，黄雨婷等，高重现性表面增强拉曼散射的基底材料及其使用方法，中国发明专利，申请号：201910333986.7。

会议报告：

18. M.K. Fan, Quantitative SERS, The plasmonic NPs suspension formed self-healing 3D liquid free-standing membrane platform approach, 21st International Symposium on Advances in Extraction Technologies, Guangzhou, 2019.11

17. M.K. Fan,The Development of Dual Functional Flexible SERS Substrates and Their Applications in Food Safety and Homeland Security, 第十届全国环境化学大会，天津，2019.08

16. M.K. Fan, Surprising Improvement on SERS Reproducibility in MNPs-Suspension-Formed 3D Free-standing Membrane，102nd Canadian Chemistry Conference and Exibition, Quebec, Canada, 2019.06

15. M.K. Fan, Developing shape adaptable surface enhanced Raman scattering (SERS) substrates for surface contamination analysis, Pacifichem 2015, Honolulu, U.S.A., 2015

14. Invited talk, Developing shape adaptable SERS substrate for surface contamination analysis, Southwest China Regional Workshop for Analytical Chemistry, Chengdu, China, 2014

13. Invited talk, Application of surface enhanced Raman scattering technique in environmental monitoring and food quality assurance, West China Normal University, Nanchong, China, 2013.

12. Invited talk, When surface enhanced Raman scattering meets homeland security and food quality assurance, Dalian Polytechnic University, Dalian, China, 2012.

11. M. K. Fan,* et al, Green route for fabrication of superhydrophobic surface enhanced Raman scattering dual functional platform by ultrasound assisted electroless deposition of silver on sandpaper (oral), 97th Canadian Chemistry Conference and Exhibition, Vancouver, Canada, 2014.

10. M. K. Fan,* et al, Sub-attomolar sensitivity through directed pre-concentration on super-hydrophobic surface using an SERS optrode (poster), 2nd international conference on frontiers of plasmonics, Chengdu, China, 2012.

9. M. K. Fan, A. G. Brolo, Layer-by-layer fabrication of SERS optrode and its application in bio-analysis (oral), 11th Asian conference for analytical science, Nanjing, China, 2011.

8. M. K. Fan, A. G. Brolo, Silver nanoparticles on a plastic platforms for bio-sensing (oral), 93rd Canadian Chemistry Conference and Exhibition, Toronto, Canada, 2010

7. M. K. Fan,  G. F. S. Andrade, A. G. Brolo, Multilayer Silver Nanoparticles Modified Optical Fiber Tip for High Performance SERS Remote Sensing (oral), 217th Electrochemical Society Meeting, Vancouver, 2010

6. M. K. Fan, M. Thompson, M. L. Andrade, A. G. Brolo, Localized surface plasmon (LSPR)-based sensor on plastics: metallic NPs on polyethylene terephthalate (PET) film as versatile platforms for bio-sensing (poster), Second BiopSys All Network Meeting ( ANM-2), Toronto, 2009

5. G. F. S. Andrade, M. K. Fan, J. G. Hayashi, A. M. Brito-Silva, M. M. Rahman, A. G. Brolo, Plasmonic modification of optical fibres for remote diagnosis: devices development (poster), Second BiopSys All Network Meeting ( ANM-2), Toronto, 2009

4. M. K. Fan, A. G. Brolo, H.-L. Chou, F.-J. Lai, W.-T. Lu, B.-J. Hwang, Probe specific surface enhanced Raman scattering (SERS) in Au:Ag nanoparticle alloys(oral), 92nd Canadian Chemistry Conference and Exhibition, Hamilton, Canada, 2009

3. M. K. Fan, A. G. Brolo, Self-assembly Ag NPs as SERS substrate with near single molecule sensitivity and low spatial variation (poster), the 13th Annual Meeting of the Pacific Center for Advanced Materials and Microstructures (PCAMM), Victoria, Canada, 2008

2. M. K. Fan, A. Finn, M. Maréchal, D. Harrington, A. G. Brolo, New SERS substrate development and its application in Biofuel cell research (oral), 91st Canadian Chemistry Conference and Exhibition, Edmonton, Canada, 2008

1. M. K. Fan, A. Finn, M. Maréchal, D. Harrington, A. G. Brolo, Characterizing a Biofuel Cell Anode by Surface-Enhanced Raman Scattering (SERS) (poster), the 58th Annual Meeting of the International Society of Electrochemistry, Banff, Canada, 2007