研究领域

• Recent Research Topics

  Topic 1: Single Polymer Chain upon  Stretching: Physical Models vs Experimental Results

  Modeling Single Chain Elasticity of Single-stranded DNA: a Comparison of  Three Models. Polymer, 2009, 50, 930-935. [Link] [Database]

  Inherent Stretching Elasticity of a Single Polymer Chain with a  Carbon-Carbon Backbone. Langmuir, 2013, 29, 4315¨C4319. [Link]

  How Big Is Big Enough? Effect of Length and Shape of Side Chains on the Single-Chain Enthalpic Elasticity of a Macromolecule. Macromolecule, 2016, 49, 3559−3565. [Link]

  The unexpected flexibility of  natural cellulose at a single-chain level and its implications to the  design of nano materials. Nanoscale, 2014, 6, 13421-13424. [Link]

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  Topic 2: The Impact of Water on the  Single-chain Mechanics of Biomacromolecules

  Weakly bound water molecules shorten single-stranded DNA. J. Am. Chem. Soc. 2006, 128, 6636-6639. [Link]

  Effects of Water on the Single-Chain Elasticity of Poly(U) RNA. Langmuir 2015, 31, 6107-6113. [Link]

  Double Stranded DNA Dissociates into Single Strands when  Dragged into a Poor Solvent. J. Am. Chem. Soc., 2007, 129, 14710-14716. [Link]

  Protein denaturation at a  single-molecule level: the effect of nonpolar environments and its  implications on the unfolding mechanism by proteases. Nanoscale, 2015, 7, 2970-2977. [Link]

  Effects of Water Content of the Mixed Solvent on the Single- Molecule Mechanics of Amylose. ACS Macro Lett., 2018, 7, 672-676. [Link]

  The Possible Roles of Water in the Prebiotic Chemical  Evolution of DNA. Phys. Chem. Chem. Phys. 2010, 12, 10147-10153. [Link]

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  Topic 3: Single-chain Mechanics of  Environmental Responsive Polymers

  Unexpected Temperature-Dependent Single Chain Mechanics  of Poly(N-isopropyl-acrylamide) in Water. Langmuir, 2012, 28, 5151-5157. [Link]

  
  

论文成果 More>>

• Poly(ethylene glycol) becomes a supra-polyelectrolyte by capturing hydronium ions in water..Macromolecules,2022,55:4656–4664.
• Effect of intramolecular hydrogen bonds on the single-chain elasticity of poly(vinyl alcohol): Evidencing the synergistic enhancement effect at the single-molecule level..Macromolecules,2021,54:7314-7320.
• Environment-dependent single-chain mechanics of synthetic polymers and biomacromolecules by atomic force microscopy-based single-molecule force spectroscopy and the implications on advanced polymer materials..Chem. Soc. Rev. 2020, 49, 2799-2827.,2020,49:2799-2827.
• Force-induced transition of π-π stacking in a single polystyrene chain.,S.,Cui,Y.;,Z.,Lu,M.;,L.,C.;,Xiao,J.;,Wei,L.;,Qian,D.;,Xu,W.;,Cai. J. Am. Chem. Soc.(2019, 141):9500-9503.
• Towards unveiling the exact molecular structure of amorphous red phosphorus by single-molecule studies.,S.,Cui,L.;,Chi,M.;,Lu,Ju,Z.;,Liu,H.;,Qian,S.;,Zhang.Angew. Chem. Int. Ed(2019, 58):1659-1663.

专利

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著作成果

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科研项目 More>>

• 磷和硼单质链状分子的单分子力谱研究
• 天然纤维素和直链淀粉与水相互作用的单链力谱研究
• 离子特异性效应对高分子与水相互作用影响的单链力谱研究
• 生物大分子单链力学
• 温敏聚合物的单分子力谱研究