杨志禄

研究员

研究员 博士生导师

电子邮箱:

所在单位:材料科学与工程学院

学历:博士研究生毕业

学位:工学博士学位

职称:研究员

博士生导师

论文成果

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学术论文

目前,以第一/通讯作者PNAS(IF=11.205)Nature Communications (IF=14.919),Research, Advanced Science(IF=16.806)Biomaterials(IF=12.479)Small(IF=13.281),Bioactive Materials(IF=14.593)等国际期刊上共发表SCI收录论文50余篇其中IF>10的论文22篇,论文平均IF>9,论文总引用2500余次。(注:* 表示通讯作者,#表示共同第一作者)

第一及通讯作者论文


2022

52. Jie Sun, Yingkang Huang, Huan Zhao, Junjie Niu, Xuwei Ling, Can Zhu, Lin Wang, Huilin Yang,  Zhilu Yang*, Guoqing Pan*, Qin Shi*. Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation. Bioactive Materials2022;9:1-14.

51. Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen*,  Zhilu Yang*. Advances in hydrogel-based vascularized tissues for tissue repair and drug screening. Bioactive Materials. 2022;9:198-220.


2021

50. Yin Chen#, Peng Gao#, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou*, Zhilu Yang*Hongkai Wu*. A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent. Nature Communications. 2021;12:7079.

49. Qing Ma#, Xiuying Shi#, Xing Tan, Rui Wang, Kaiqin Xiong, Manfred F. Maitz, Yuanyuan Cui, Zhangmei Hu, Qiufen Tu*, Nan Huang, Li Shen*Zhilu Yang*. Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents. Bioactive Materials. 2021;12:4786-4800.

48. Han Yu#, Hua Qiu#, Wenmei Ma, Manfred F. Maitz, Qiufen Tu, Kaiqin Xiong, Jiang Chen*, Nan Huang*, Zhilu Yang*Endothelium-Mimicking Surface Combats Thrombosis and Biofouling via Synergistic Long- and Short-Distance Defense Strategy. Small2021;2100729. 

47. Wenxuan Wang#, Lei Lu#, Bei Ho Pan#, Xiangyang Li, Zeyu Du, Manfred F. Maitz, Qiufen Tu*, Nan Huang, Xin Zhao*Zhilu Yang*. Self-protonating, plasma polymerized, superimposed multi-layered biomolecule nanoreservoir as blood-contacting surfaces. Chemical Engineering Journal2021;410:128313.

46. Hua Qiu, Qiufen Tu, Peng Gao, Xiangyang Li, Manfred F. Maitz, Kaiqin Xiong*, Nan Huang, Zhilu Yang*Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents. Biomaterials. 2021269:120626.

45. Han Yu, Shaoxing Yu, Hua Qiu, Peng Gao, Yingzhong Chen, Xin Zhao, Qiufen Tu, Minggang Zhou*, Lin Cai, Nan Huang, Kaiqin Xiong*Zhilu Yang*. Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions. Bioactive Materials. 2021;6:1618–1627.


2020

44. Nan Lyu, Zeyu Du, Hua Qiu, Peng Gao, Qin Yao, Kaiqin Xiong, Qiufen Tu, Xiangyang Li, Binghai Chen, Guoqing Pan*, Nan Huang*, Zhilu Yang*. Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces. Advanced Science. 2020;7:202002330.

43. Zhilu Yang#, Xin Zhao#, Rui Hao, Qiufen Tu, Xiaohua Tian, Yu Xiao, Kaiqin Xiong, Miao Wang, Yonghai Feng, Nan Huang*, Guoqing Pan*.Bio-clickable and Mussel Adhesive Peptide Mimics for Engineering Vascular Stent Surfaces. PNAS 2020;117:16127-16137

42. Yu Xiao, Wenxuan Wang, Xiaohua Tian, Xing Tan, Tong Yang, Peng Gao, Kaiqing Xiong, Qiufen Tu, Miao Wang, Manfred F. Maitz, Nan Huang, Guoqing Pan*,  Zhilu Yang*. A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic. Research2020;2020:7236946.

41. Ying Yang, Peng Gao, Juan Wang, Qiufen Tu, Long Bai, Kaiqin Xiong, Hua Qiu, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Xiangyang Li, Qiang Zhao, Yin Xiao, Nan Huang*, Zhilu Yang*. Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy. Research2020;2020:9203906.

40. Peng Gao, Hua Qiu, Kaiqin Xiong, Xiangyang Li, Qiufen Tu, Huaiyu Wang, Nan Lyu, Xiao Chen,  Nan Huang*, Zhilu Yang* Metal-Catechol-(Amine) Networks for Surface Synergistic Catalytic Modification: Therapeutic Gas Generation and Biomolecule Grafting. Biomaterials. 2020;248:119981. 

39. Xiangyang Li#, Jingxia Liu#, Tong Yang, Hua Qiu, Lei Lu, Qiufen Tu, Kaiqing Xiong, Nan Huang*, Zhilu Yang*Mussel-inspired “built-up” surface chemistry for combining nitric oxide catalytic and vascular cell selective properties. Biomaterials2020;241:119904

38. Tong Yang, Zeyu Du, Hua Qiu, Peng Gao, Xin Zhao, Huaiyu Wang, Qiufen Tu, Kaiqin Xiong, Nan Huang, Zhilu Yang*. From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials2020;5:17-25.

37. Qiufen Tu#, Xin Zhao#, Shuai Liu, Xiangyang Li, Qiang Zhang, Han Yu, Kaiqin Xiong, Nan Huang, Zhilu Yang*. Spatiotemporal Dual-Delivery of Therapeutic Gas and Growth Factor for Prevention of Vascular Stent Thrombosis and Restenosis. Applied Materials Today2020;19:100546.


2019

36. Han Yu, Linxian Cui, Nan Huang*, Zhilu Yang*. Recent developments in nitric oxide-releasing biomaterials for biomedical applications. Medical Gas Research. 2019;9:184-191.

35. Donghai Yu, Xiaohui Mou, Zhenglong Dou, Ningling Zhou, Qianru Guo, Nan Lv, Lei Lv, Zhilu Yang*, Nan Huang*. “One-pot but Two-step” Vapor-based Amine- and Fluorine-bearing Dual-layer Coating for Improving Anti-corrosion and Biocompatibility of Magnesium Alloy. ACS Biomaterials Science & Engineering. 2019;5:4331-4340.

34. Feng Qiao, Qianru Guo, Qiufen Tu, Jing Lu, Jin Wang, Wenjie Tian*, Kaiqin Xiong*, Nan Huang, Zhilu Yang*. Photolithography-Mediated Area-Selective Immobilization of Biomolecules on Polydopamine Coating. Langmuir. 2019; 35:7175-7179.

33. Hua Qiu#, Pengkai Qi#, Xing Tan, Yu Xiao, Jingxia Liu, Lei Lu, Peng Gao, Ying Yang, Nan Huang*Zhilu Yang*. Biomimetic Engineering Endothelium-like Coating on Cardiovascular Stent through Heparin and Nitric Oxide-Generating Compound Synergic Modification Strategy. Biomaterials. 2019;207:10-22. 

32. Qiufen Tu#, Xuehong Shen#, Yaowen Liu, Qiang Zhang, Xin Zhao, Manfred F. Maitz, Tao Liu, Hua Qiu, Jin Wang, Nan Huang*Zhilu Yang*. A facile metal-phenolic-amine strategy for dual-functionalization of blood-contacting devices with antibacterial and anticoagulant properties. Materials Chemistry Frontiers. 2019;3:265-275.

31. Feng Zhang#, Qiang Zhang#, Xiangyang Li, Nan Huang, Xin Zhao*Zhilu Yang*. Mussel-inspired dopamine-CuII coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis. Biomaterials. 2019;194:117-129.


2018

30. Xiangyang Li, Peng Gao, Jianying Tan, Kaiqin Xiong, Changjiang Pan, Hongkai Wu, Yin Chen, Zhilu Yang*, Nan Huang*. Assembly of Metal-Phenolic/Catecholamine Networks for Synergistically Anti-Inflammatory, Antimicrobial and Anticoagulant Coatings. ACS Applied Materials & Interfaces. 2018;10:40844-40853.

29Zhilu Yang*, Ying Yang, Kaiqin Xiong, Jin Wang, Haeshin Lee*, Nan Huang*, Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas. Chemistry of Materials2018;30:5220-5226.

28Zhilu Yang*, Ying Yang, Li Zhang, Kaiqin Xiong, Xiangyang Li, Feng Zhang, Jin Wang, Xin Zhao*, Nan Huang*, Mussel-inspired Catalytic Selenocystamine-Dopamine Coatings for Long-Term Generation of Therapeutic Gas on Cardiovascular Stents. Biomaterials. 2018;178:1-10.

27Zhilu Yang*, Hua Qiu, Xiangyang Li, Peng Gao, Nan Huang*, Plant-inspired gallolamine catalytic surface chemistry for engineering an efficient nitric oxide generating coating. Acta Biomaterialia2018;76:89-98.

26. Xiangyang Li, Hua Qiu, Peng Gao, Ying Yang, Zhilu Yang*, Nan Huang*, Synergetic coordination- and catecholamine chemistry for catalytic generation of nitric oxide on vascular stents. NPG Asia Materials2018;10:482-496.

25. Ying Yang, Xiangyang Li, Hua Qiu, Ping Li, Manfred F. Maitz, Tianxue You, Ru Shen, Zhilu Yang*, Wenjie Tian*, and Nan Huang*. Polydopamine modified TiO2 nanotube arrays for long term controlled elution of bivalirudin and improved hemocompatibility. ACS Applied Materials & Interfaces2018;10:7649−7660.

2017-2015

24. Pengkai Qi, Ying Yang, Sheng Zhao, Juan Wang, Xiangyang Li, Qiufen Tu*, Zhilu Yang*, Nan Huang*. Improvement of corrosion resistance and biocompatibility of biodegradable metallic vascular stent via plasma allylamine polymerized coating. Materials and Design. 2016;96:341-349.

23. Kaiqin Xiong, Pengkai Qi, Ying Yang, Xiangyang Li, Hua Qiu, Xin Li, Ru Shen, Zhilu Yang*Qiufen Tu*, Nan Huang*. Facile immobilization of vascular endothelial growth factor on tannic acid-functionalized plasma-polymerized allylamine coating rich in quinone groups. RSC Advance. 2016;6:17188-17195.

22. Ying Yang, Pengkai Qi, Xiangyang Li, Yalong Li, Zhilu Yang*, Qiufen Tu, Nan Huang*. Development of nitric oxide catalytic coatings by Conjugating 3,3-disulfodipropionic acid and 3,3-diselenodipropionic acid for improving hemocompatibility. Biointerphases. 2015;10(4)A303-8

21. Ying Yang Pengkai Qi, Zhilu Yang*, Nan Huang*. Nitric oxide based strategies for applications of biomedical devices (Review). Biosurface and Biotribology. 2015;1(3):177-201.

20. Zhilu Yang*, Ying Yang, Kaiqin Xiong, Xiangyang Li, Pengkai Qi, Qiufen Tu, Fengjuan Jing, Yajun Weng, Jin Wang*, Nan Huang*. Nitric oxide producing coating mimicking endothelium function for multifunctional vascular stents. Biomaterials. 2015;63:80-92. 

19. Pengkai Qi, Ying Yang, Kaiqin Xiong, Qiufen Tu, Zhilu Yang*, Jin Wang, Junying Chen, Nan Huang*. Multifunctional plasma polymerized film: towards better anti-corrosion property, enhanced cellular growth ability, attenuated inflammatory and histological responses. ACS Biomaterials Science & Engineering.2015;1:513-524.

18. Pengkai Qi, Wei Yan, Ying Yang, Yalong Li, Baolong Ma, Yi Fan, Zhilu Yang*, Qiufen Tu*, Nan Huang*. Immobilization of DNA aptamers via plasma polymerized allylamine film to construct an endothelial progenitor cell-capture surface. Colloids and Surfaces B: Biointerfaces. 2015;126:70-79.

17. Ying Yang, Pengkai Qi, Yonghui Ding, Manfred F. Maitz, Zhilu Yang*, Qiufen Tu, Kaiqin Xiong, Yang Leng, Nan Huang*. A biocompatible and functional adhesive amine-rich coating based on dopamine polymerization. Journal of Materials and Chemistry: B. 2015;3:72-81.

Before PI (2014-2009)

16Zhilu Yang*, Si Zhong, Ying Yang, Manfred F. Maitz, Xiangyang Li, Qiufen Tu, Pengkai Qi, Heng Zhang, Hua Qiu, Jin Wang, Nan Huang. Polydopamine-mediated long-term elution of the direct thrombin inhibitor bivalirudin from TiO2 nanotubes for improved vascular biocompatibility. Journal of Materials and Chemistry: B. 2014;2:6767-6778.

15. Zhilu Yang*, Kaiqin Xiong, Pengkai Qi, Ying Yang, Qiufen Tu, Jin Wang*, Nan Huang*. Gallic acid tailoring surface functionalities of plasma-polymerized allylamine-coated 316L SS to selectively direct vascular endothelial and smooth muscle cell fate for enhanced endothelialization. ACS Applied Materials & Interfaces. 2014;6:2647-2656. 

14. Ying Yang, Pengkai Qi, Feng Wen, Xiangyang Li, Qin Xia, Manfred F. Maitz, Zhilu Yang*, Ru Shen, Qiufen Tu, Nan Huang*. Mussel-inspired one-step adherent coating rich in amine groups for covalent immobilization of heparin: hemocompatibility, growth behaviors of vascular cells and tissue response. ACS Applied Materials & Interfaces. 2014;6:14608-14620.

13. Pengkai Qi, Ying Yang, Xiangyang Li, Ru Shen, Jin Wang, Zhilu Yang*, Qiufen Tu*, Nan Huang*. Constructing biomimic catalytic coating with controlled nitric oxide release properties by immobilizing 3,3-diselenodipropionic acid on plasma polymerized allylamine film. Plasma Processes and Polymers. 2014;10:952-960.

12. Zhilu Yang#,*, Ying Yang#, Wei Yan, Qiufen Tu*, Jin Wang*, Nan Huang. Construction of polyfunctional coatings assisted by gallic acid to facilitate co-immobilization of diverse biomolecules. ACS Applied Materials & Interfaces. 2013;5:10495-10501. 

11. Zhilu Yang, Qiufen Tu*, Manfred F. Maitz, Shou Zhou, Jin Wang, Nan Huang*. Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices. Biomaterials. 2012;33:7959-7971. 

10. Zhilu Yang, Qiufen Tu, Ying Zhu, Rifang Luo, Xin li, Yichu Xie, Manfred F. Maitz, Jin Wang*, Nan Huang*. Mussel-inspired coating of polydopamine directs endothelial and smooth muscle cell fate for re-endothelialization of vascular devices. Advanced Healthcare Materials. 2012;1:548-559.

9. Zhilu Yang*, Qiufen Tu, Jin Wang*, Nan Huang*. The role of heparin binding surface in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials. 2012;33:6615-6625.

8. Zhilu Yang#, Shuo Zhou#, Lei Lu, Xin Wang, Jin Wang*, Nan Huang*. Construction and hemocompatibility study of highly bioactive heparin-functionalized surface. Journal of Biomedical Materials Research: Part A. 2012;100A:3124-3133.

7. Zhilu Yang, Jing Wu, Xin Wang, Jin Wang*, Nan Huang*. Inspired chemistry for a simple but highly effective immobilization of vascular endothelial growth factor on gallic acid-functionalized plasma polymerized film. Plasma Processes and Polymers. 2012;9:718-725.

6. Zhilu Yang, Jin Wang*, Xin Li, Qiufen Tu, Hong Sun, Nan Huang. Interaction of platelets, fibrinogen and endothelial cells with plasma deposited PEO-like films. Applied Surface Science. 2012;258:3378-3385.

5. Zhilu Yang, Jin Wang*, Rifang Luo, Tingting He, Si Chen, Xingjiang Lei, Hong Sun, Nan Huang. Improved hemocompatibility guided by pulsed plasma tailoring the surface amino functionalities of TiO2 coating for covalent immobilization of heparin. Plasma Processes and Polymers. 2011;8:850-858.

4. Zhilu Yang, Qiufen Tu, Jin Wang*, Xingjiang Lei, Tingting He, Hong Sun, Nan Huang. Bioactive plasma-polymerized bipolar films for enhanced endothelial cellular mobility. Macromolecular Bioscience. 2011;11:797-805.

3. Zhilu Yang, Xingjiang Lei, Jin Wang*, Rifang Luo, Tingting He, Hong Sun, Nan Huang. A novel technique toward bipolar films containing alternating nano–layers of allylamine and acrylic acid plasma polymers for biomedical application. Plasma Processes and Polymers. 2011;8:208-214. (Cover)

2. Zhilu Yang, Jin Wang*, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials. 2010;31:2072–2083. 

1. Zhilu Yang, Xiaona Wang, Jin Wang*, Ye Yao, Hong Sun, Nan Huang. Pulsed plasma polymeric allylamine thin films. Plasma Processes and Polymers. 2009;6:498-505.

合著论文


16. Dashuai Zhu, Jingli Hou, Meng Qian, Dawei Jin, Tian Hao, Yanjun Pan, He Wang, Shuting Wu, Shuo Liu, Fei Wang, Lanping Wu, Yumin Zhong, Zhilu Yang, Yongzhe Che, Jie Shen, Deling Kong, Meng Yin*, Qiang Zhao*. Nitrate-functionalized patch confers cardioprotection and improves heart repair after myocardial infarction via local nitric oxide delivery. Nature Communications, 2021;12:1-16.

15. Zhijun Ma, Qiyao Huang, Qi Xu, Qiuna Zhuang, Xin Zhao, Yuhe Yang, Hua Qiu, Zhilu Yang, Cong Wang, Yang Chai, Zijian Zheng*. Permeable superelastic liquid-metal fibre mat enables biocompatible and monolithic stretchable electronics. Nature Materials, 2021;20:859-868..

14. Yujie Zhang, Mingxin Wu, Wubin Dai, Yinping Li, Xin Wang, Di Tan, Zhilu Yang, Sheng Liu, Longjian Xue, Yifeng Lei*. Gold nanoclusters for controlled insulin release and glucose regulation in diabetes. Nanoscale. 2019;13: 6471-6479.

13. Qiang Song, Long Li, Kaiqin Xiong, Wenjie Tian, Jing Lu, Jin Wang, Nan Huang*, Qiufen Tu*Zhilu Yang. A facile dopamine-mediated metal-catecholamine coating for therapeutic nitric oxide gas interface-catalytic engineering of vascular devices. Biomaterials science. 2019;7:3741-3750.

12. Ruixia Hou, Leigang Wu, Yabin Zhu*, Jin Wang*, Zhilu Yang, Qiufen Tu, Nan Huang*. Study of functional drug-eluting stent in promoting endothelialization and antiproliferation. Journal of Biomaterials Science. Polymer Edition. 2019;5:1-17.

11. Ruixia Hou*, Leigang Wu, Jin Wang, Zhilu Yang, Qiufen Tu, Xingcai Zhang*, Nan Huang*. Surface-Degradable Drug-Eluting Stent with Anticoagulation, Antiproliferation, and Endothelialization Functions. Biomolecules. 2019;9:69.

10. Yonghui Ding, Meng Yang, Zhilu Yang, Rifang Luo, Xiong Lu, Nan Huang, Pingbo Huang, Yang Leng. Cooperative control of blood compatibility and re-endothelialization by immobilized heparin and substrate topography. Acta Biomaterialia. 2015;15:150-163.

9. Yonghui Ding, Lu-Tao Weng, Meng Yang, Zhilu Yang, Xiong Lu, Nan Huang, Yang Leng. Insights into aggregation/depositionand structure of polydopamine film. Langmuir. 2014;30:12258-12269.

8. Yonghui Ding, Zhilu Yang, Cathy WC Bi, Meng Yang, Jingcheng Zhang, Sherry Li Xu, Xiong Lu, Nan Huang, Pingbo Huang, Yang Leng. Modulation of protein adsorption, vascular cell selectivity and platelet adhesionby mussel-inspired surface functionalization. Journal of Materials and Chemistry: B. 2014;2:3819-3829.

7. Yonghui Ding, Zhilu Yang, Cathy W. C. Bi, Meng Yang, Sherry Li Xu, Xiong Lu, Nan Huang, Pingbo Huang, Yang Leng. Directing vascular cell-selectivity and hemocompatibility on patterned platforms featuring variable topographic geometry and size. ACS Applied Materials & Interfaces. 2014;6:12062-12070.

6. Pengkai Qi, Si Chen, Tao Liu, Jialong Chen, Zhilu Yang, Yajun Weng, Junying Chen, Jin Wang, Manfred F. Maitz, Nan Huang. New strategies for developing cardiovascular stent surfaces with novel functions (Review). Biointerphases. 2014;9:1-13.

5. Si Chen, Xin Li, Zhilu Yang, Shuo Zhou, Rifang Luo, Manfred F. Maitz, Yuanchong Zhao, Jin Wang. Kaiqin Xiong, Nan Huang. A simple one-step modification of various materials for introducing effective multi-functional groups. Colloids and Surfaces B: Biointerfaces. 2013;113:125-133.

4. Rifang Luo, Linlin Tang, Si Zhong, Zhilu Yang, Jin Wang, Yajun Weng, Qiufen Tu, Chongxi Jiang, Nan Huang. In vitro investigation of enhanced hemocompatibility and endothelial cell proliferation associated with quinone-rich polydopamine coating. ACS Applied Materials & Interfaces. 2013;5:1704-1714.

3. Qiufen Tu, Zhilu Yang, Ying Zhu, Kaiqin Xiong, Manfred F. Maitz, Jin Wang, Yuancong Zhao, Nan Huang, Jian Jin, Yuechang Lei. Effect of tissue specificity on the performance of extracellular matrix in improving endothelialization of cardiovascular implants. Tissue Engineering: Part A. 2013;19:91-102.

2. Tingting He, Zhilu Yang, Rui Chen, Jin Wang, Yongxiang Leng, Hong Sun, Nan Huang. Enhanced endothelialization guided by fibronectin functionalized plasma polymerized acrylic acid film. Materials Science and Engineering: C. 2012;32:1025-1031.

1. Xiaona Wang, Jin Wang, Zhilu Yang, Yongxiang Leng, Hong Sun, Nan Huang. Structural characterization and mechanical properties of functionalized pulsed-plasma polymerized allylamine film. Surface and Coatings Technology. 2010;204:3047-3052.