杨志禄

研究员

研究员 博士生导师

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所在单位:材料科学与工程学院

学历:博士研究生毕业

学位:工学博士学位

职称:研究员

博士生导师

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个人简介

杨志禄,工学博士,研究员,博士生导师,西南交通大学“扬华学者”四川省杰出青年基金获得者。中国生物材料学会科学技术奖一等奖获得者(排名:2/7)。现任KeAi旗下国际期刊Smart Materials in Medicine创刊主编、中国科协旗舰刊Research副主编(Deputy Editor)、Bioactive Materials(IF: 14.593,生物材料领域排名第一)及Engineered Regeneration编委。目前,担任中国生物材料学会康复器械与生物材料分会常务委员、中国病理生理学会专业委员会青年委员、中国生物材料学会医用金属材料分会委员,中国生物材料学会血液净化材料分会委员,中国生物材料学会生物材料表界面工程分会委员,中国腐蚀与防护学会医用金属材料腐蚀控制分会委员。主要研究方向聚焦于:1)心血管动脉粥样硬化病理发病机制、以及用于心血管疾病治疗的纳米靶向药物、药物球囊及具有病变血管组织再生修复及病灶治愈功能的冠脉、外周及颅内血管支架;2)心血管植入/介入器械芯片;3)具有长效抗凝、抗感染和超润滑性功能的导管;4)可回收下腔静脉滤器。以通讯/第一作者在包括PNAS (IF=11.205),   Nature Communications (IF=14.919),Research(Science创刊以来的第一本合作期刊,2篇Advanced Science (IF=16.806),  Biomaterials (IF=12.479,10篇),Small(IF=13.281)及Bioactive Materials(IF=14.593)等国际知名期刊上共发表SCI收录论文50余篇 (其中IF>10的论文23篇,论文平均IF>9)。获得授权发明专利19项(包括美国发明专利1项)。主导发展的具有完全自主知识产权的“基于一氧化氮催化释放的内皮功能仿生血管支架涂层技术”已成功实现转让(转让费:1500万),基于该核心涂层技术研发的新一代心血管支架进入到产业化工程和申报检验阶段


Selected Publications:

23. Xiaohui Mou#, Hongbo Zhang#, Hua Qiu#, Wentai Zhang, Ying Wang, Kaiqin Xiong, Nan Huang*, Hélder A. Santos*, Zhilu Yang*. Mussel-inspired and bioclickable peptide engineered surface to combat thrombosis and infection. Research2022;9780879.

22. Jie Sun, Yingkang Huang, Huan Zhao, Junjie Niu, Xuwei Ling, Can Zhu, Lin Wang, Huilin Yang,  Zhilu Yang*, Guoqing Pan*, Qin Shi*. Bio-clickable mussel-inspired peptides improve titanium-based material osseointegration synergistically with immunopolarization-regulation. Bioactive Materials. 2022;9:1-14.

21. Ying Wang, Ranjith Kumar Kankala, Caiwen Ou, Aizheng Chen*,  Zhilu Yang*. Advances in hydrogel-based vascularized tissues for tissue repair and drug screening. Bioactive Materials. 2022;9:198-220.

20. Yin Chen#, Peng Gao#, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou*, Zhilu Yang*, Hongkai Wu*. A tough nitric oxide-eluting hydrogel coating suppresses neointimal hyperplasia on vascular stent. Nature Communications. 2021;12:7079.

19. Qing Ma#, Xiuying Shi#, Xing Tan, Rui Wang, Kaiqin Xiong, Manfred F. Maitz, Yuanyuan Cui, Zhangmei Hu, Qiufen Tu*, Nan Huang, Li Shen*Zhilu Yang*. Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents. Bioactive Materials. 2021;12:4786-4800.

18. Han Yu#, Hua Qiu#, Wenmei Ma, Manfred F. Maitz, Qiufen Tu, Kaiqin Xiong, Jiang Chen*, Nan Huang*, Zhilu Yang*Endothelium-Mimicking Surface Combats Thrombosis and Biofouling via Synergistic Long- and Short-Distance Defense Strategy. Small2021;2100729. 

17. Hua Qiu, Qiufen Tu, Peng Gao, Xiangyang Li, Manfred F. Maitz, Kaiqin Xiong*, Nan HuangZhilu Yang*Phenolic-amine chemistry mediated synergistic modification with polyphenols and thrombin inhibitor for combating the thrombosis and inflammation of cardiovascular stents. Biomaterials. 2021269:120626.

16. Han Yu, Shaoxing Yu, Hua Qiu, Peng Gao, Yingzhong Chen, Xin Zhao, Qiufen Tu, Minggang Zhou*, Lin Cai, Nan Huang, Kaiqin Xiong*Zhilu Yang*. Nitric oxide-generating compound and bio-clickable peptide mimic for synergistically tailoring surface anti-thrombogenic and anti-microbial dual-functions. Bioactive Materials. 2021;6:1618–1627.

15. Nan Lyu, Zeyu Du, Hua Qiu, Peng Gao, Qin Yao, Kaiqin Xiong, Qiufen Tu, Xiangyang Li, Binghai Chen, Guoqing Pan*, Nan Huang*Zhilu Yang*Mimicking the Nitric Oxide-Releasing and Glycocalyx Functions of Endothelium on Vascular Stent Surfaces. Advanced Science2020;7:202002330.

14. Zhilu Yang#Xin Zhao#, Rui Hao, Qiufen Tu, Xiaohua Tian, Yu Xiao, Kaiqin Xiong, Miao Wang, Yonghai Feng, Nan Huang*, Guoqing Pan*. Bio-clickable and Mussel Adhesive Peptide Mimics for Engineering Vascular Stent SurfacesPNAS2020;117:16127-16137

13. Yu Xiao, Wenxuan Wang, Xiaohua Tian, Xing Tan, Tong Yang, Peng Gao, Kaiqing Xiong, Qiufen Tu, Miao Wang, Manfred F. Maitz, Nan Huang, Guoqing Pan*,  Zhilu Yang*A Versatile Surface Bioengineering Strategy Based on Mussel-Inspired and Bioclickable Peptide Mimic.  Research2020;2020:7236946.

12. Ying Yang, Peng Gao, Juan Wang, Qiufen Tu, Long Bai, Kaiqin Xiong, Hua Qiu, Xin Zhao, Manfred F. Maitz, Huaiyu Wang, Xiangyang Li, Qiang Zhao, Yin Xiao, Nan Huang*Zhilu Yang*Endothelium-Mimicking Multifunctional Coating Modified Cardiovascular Stents via a Stepwise Metal-Catechol-(Amine) Surface Engineering Strategy. Research2020;2020:9203906.

11. Peng Gao, Hua Qiu, Kaiqin Xiong, Xiangyang Li, Qiufen Tu, Huaiyu Wang, Nan Lyu, Xiao Chen,  Nan Huang*Zhilu Yang*.  Metal-Catechol-(Amine) Networks for Surface Synergistic Catalytic Modification: Therapeutic Gas Generation and Biomolecule Grafting. Biomaterials2020;248:119981

10. Tong Yang, Zeyu Du, Hua Qiu, Peng Gao, Xin Zhao, Huaiyu Wang, Qiufen Tu, Kaiqin Xiong, Nan Huang, Zhilu Yang*. From surface to bulk modification: Plasma polymerization of amine-bearing coating by synergic strategy of biomolecule grafting and nitric oxide loading. Bioactive Materials2020;5:17-25.

9. Xiangyang Li#, Jingxia Liu#, Tong Yang, Hua Qiu, Lei Lu, Qiufen Tu, Kaiqing Xiong, Nan Huang*, Zhilu Yang*. Mussel-inspired “built-up” surface chemistry for combining nitric oxide catalytic and vascular cell selective properties. Biomaterials2020;241:119904.

8. Hua Qiu#, Pengkai Qi#, Xing Tan, Yu Xiao, Jingxia Liu, Lei Lu, Peng Gao, Ying Yang, Nan Huang*Zhilu Yang*. Biomimetic Engineering Endothelium-like Coating on Cardiovascular Stent through Heparin and Nitric Oxide-Generating Compound Synergic Modification Strategy. Biomaterials. 2019;207:10-22.

7. Feng Zhang#, Qiang Zhang#, Xiangyang Li, Nan Huang, Xin Zhao*Zhilu Yang*. Mussel-inspired dopamine-CuII coatings for sustained in situ generation of nitric oxide for prevention of stent thrombosis and restenosis.  Biomaterials. 2019;194:117-129.

6. Zhilu Yang*, Ying Yang, Kaiqin Xiong, Jin Wang, Haeshin Lee*, Nan Huang*, Metal-Phenolic Surfaces for Generating Therapeutic Nitric Oxide Gas. Chemistry of Materials2018;30:5220-5226.

5. Zhilu Yang*, Ying Yang, Li Zhang, Kaiqin Xiong, Xiangyang Li, Feng Zhang, Jin Wang, Xin Zhao*, Nan Huang*, Mussel-inspired Catalytic Selenocystamine-Dopamine Coatings for Long-Term Generation of Therapeutic Gas on Cardiovascular Stents. Biomaterials2018;178:1-10.

4.  Zhilu Yang*, Ying Yang, Kaiqin Xiong, Xiangyang Li, Pengkai Qi, Qiufen Tu, Fengjuan Jing, Yajun Weng, Jin Wang*, Nan Huang*. Nitric oxide producing coating mimicking endothelium function for multifunctional vascular stents. Biomaterials2015;63:80-92.

3.  Zhilu Yang, Qiufen Tu*, Manfred F. Maitz, Shou Zhou, Jin Wang, Nan Huang*. Direct thrombin inhibitor-bivalirudin functionalized plasma polymerized allylamine coating for improved biocompatibility of vascular devices. Biomaterials. 2012;33:7959-7971. 

2. Zhilu Yang*, Qiufen Tu, Jin Wang*, Nan Huang*. The role of heparin binding surface in the direction of endothelial and smooth muscle cell fate and re-endothelialization. Biomaterials2012;33:6615-6625. 

1.  Zhilu Yang, Jin Wang*, Rifang Luo, Manfred F. Maitz, Fengjuan Jing, Hong Sun, Nan Huang. The covalent immobilization of heparin to pulsed-plasma polymeric allylamine films on 316L stainless steel and the resulting effects on hemocompatibility. Biomaterials2010;31:2072–2083.

教育经历

[1] 2009.9-2014.6
西南交通大学 | 材料学 | 博士研究生毕业 | 工学博士学位
[2] 2005.9-2008.7
西南交通大学 | 材料物理与化学 | 硕士研究生毕业 | 工学硕士学位
[3] 2001.9-2005.7
南昌航空工业学院 | 高分子材料与工程 | 大学本科毕业 | 工学学士学位

工作经历

[1] 2019.12-至今
西南交通大学 | 研究员 
[2] 2015.4-2019.12
西南交通大学 | 副教授 

社会兼职

[1] 担任Smart materials in medicine 国际期刊主编
[2] 担任中国科协旗舰刊Research副主编(Deputy Editor)
[3] 担任Bioactive Materials (IF:14.593)国际期刊编委
[4] 担任Engineered Regeneration 国际期刊编委
[5] 中国病理生理学会专业委员会青年委员
[6] 中国生物材料学会医用金属材料分会委员
[7] 中国生物材料学会血液净化材料分会委员
[8] 中国生物材料学会生物材料表界面工程分会委员
[9] 担任中国生物材料学会康复器械与生物材料分会常务委员

团队成员

团队名称:科研团队

团队介绍:

科研团队主要研究方向聚焦心血管动脉粥样硬化病理发病机制、以及用于心血管疾病治疗的纳米靶向药物、药物球囊及具有病灶治愈和血管组织修复功能的血管支架等研究。