硕士生导师
个人信息Personal Information
学历：博士研究生毕业
学位：理学博士学位
毕业院校：兰州大学
所在单位：化学学院
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个人简介Personal Profile
2012-2018年硕博连读，毕业于兰州大学功能有机分子化学国家重点实验室，师从彭羽教授，主要从事木脂素类天然产物的全合成研究。2018年10月入职于西南交通大学生命科学与工程学院开展教学科研工作；2023年1月工作关系划转至化学学院，现为西南交通大学化学学院助理教授，硕士生导师。先后主持中央高校科研项目，并作为主要参与者参与多项国家自然科学基金面上项目。2019年入选西南交通大学青苗计划项目资助。在国内外主流学术杂志发表论文二十余篇，申请发明专利三件。目前主要研究方向为“功能导向的天然产物或药物分子全合成，及合成新方法研究”。
学术成果：
15. Jian Xiao*,†Zi-Hao Liu,†Zi-Fan He, Ping Wu, Ya-Wen Wang, Wei Dong Z Li,* and Yu Peng*.Bioinspired Total Synthesis of 3-epi-Junipercedrol. Org. Lett. 2024, 26, 7463-7467.
14. Jian Xiao*, Hao Wu, Jia-Rong Liang, Ping Wu, Chen Guo, Ya-Wen Wang, Zhi-Yi Wang,* and Yu Peng*. Photocatalytic Tandem Radical Cyclization Enables Expeditious Total Synthesis of Epoxyhinokiol Analogues for Anticancer Activity Evaluation. Org. Lett. 2024, 26, 3481-3486. (Front Cover; Highlighted by CBG 咨询 and Org. Lett.)
13. Zi-Hao Liu, Jian Xiao*, Qian-Qian Zhai, Xi Tang, Li-Jun Xu, Zhi-Yuan Zhuang,Ya-Wen Wanga and Yu Peng *. Intramolecular Ni-catalyzed reductive coupling enables enantiodivergent synthesis of linoxepin. Chem. Commun. 2024, 60, 694‒697.
12. Lvli Chen, Dong Xiong, Zeyu Yang, Yuyao Chen, Jian Xiao*, Yin Tian * andJianfeng Zheng*. Atom-economic metal free mediateddifunctionalization of isocyanides with3-methyleneoxindoles and 3-methylenebenzofuranones,Org. Chem. Front., 2024, 11, 5868–5875.
11. Jing-Si Cao, Jing Zeng, Jian Xiao*, Xiao-Han Wang, Ya-Wen Wang, Yu Peng*. Total Synthesis of Linoxepin Facilitated by a Ni-Catalyzed Tandem Reductive Cyclization, Chem. Commun. 2022, 58, 7273‒7276.
10. Jian Xiao, Jun Zhao, Ya-Wen Wang, Gan Luo, Yu Peng*, Total Syntheses of (+)-Adunctins C and D: Assignment of Their Absolute Configurations. Org. Biomol. Chem. 2021, 19, 9840‒9843.
9. Yu-An Feng, Hai Xu, Yang Zhou, Bao-Jun Wang, Jian Xiao*, Ya-Wen Wang*, Yu Peng*, Ratiometric Detection and Bioimaging of Endogenous Alkaline Phosphatase by a NIR Fluorescence Probe. Sens. Actuators, B. 2022, 358, 131505.
8. Hai Xu, Song-Ling Wu, Nai-Jie Lin, Yuan Lu, Jian Xiao*, Ya-Wen Wang *, Yu Peng*, A NIR Fluorescent Probe for Rapid Turn-On Detection and Bioimaging of Hypochlorite Anion. Sens. Actuators, B. 2021, 346, 130484.
7. Jian Xiao, Ya-Wen Wang, Zhong-Ping Qiu*, Yu Peng*. Ni-Catalyzed Intramolecular Reductive 1,2-Dicarbofunctionalization of Alkene: Facile Access to Podophyllum Lignans Core. Synlett 2021, 32,1662‒1664.
6. Jian Xiao, Xiao-Wei Cong, Gui-Zhen Yang, Ya-Wen Wang, Yu Peng*. Divergent Asymmetric Syntheses of Podophyllotoxin and Related Family Members via Stereoselective Reductive Ni-Catalysis. Org. Lett. 2018, 20, 1651–1654. (Highlighted by CBG咨询)
5. Jian Xiao, Xiao-Wei Cong, Gui-Zhen Yang, Ya-Wen Wang, Yu Peng*. Stereoselective Synthesis of a Podophyllum Lignan Core by Intramolecular Reductive Ni-Catalysis, Chem. Commun. 2018, 54, 2040–2043. (Highlighted by X-MOL).
4. Jian Xiao, Guang-Ming Nan, Ya-Wen Wang Yu Peng*. Concise Synthesis of (+)-β and γ-Apopicropodophyllins,and Dehydrodesoxypodophyllotoxin, Molecules 2018, 23, 3037.
3. Jian Xiao, Ya-Wen Wang, Yu Peng*. Nickel-Promoted Reductive Cyclization Cascade: A Short Synthesis of a New Aromatic Strigolactone Analogue, Synthesis 2017, 49, 3576–3581. (Special Topic: Advanced Strategies in Synthesis with Nickel).
2. Yu Peng*, Jian Xiao, Xiao-Bo Xu, Shu-Ming Duan, Li Ren, Yong-Liang Shao, Ya-Wen Wang. Stereospecific Synthesis of Tetrahydronaphtho[2,3-b]furans Enabled by a Nickel-Promoted Tandem Reductive Cyclization, Org. Lett. 2016, 18, 5170–5173. (Highlighted by Prof. Paul Knochel in Synfacts 2016, 12, 1296)
1. Yu Peng*, Xiao-Bo Xu, Jian Xiao, Ya-Wen Wang. Nickel-Mediated Stereocontrolled Synthesis of Spiroketals via Tandem Cyclization-Coupling of β-Bromo Ketals and Aryl Iodides. Chem. Commun. 2014, 50, 472–474.
综述撰写：
6. Si-Chen Yao†, Jian Xiao†, Guang-Ming Nan, Yu Peng*.Progress on total synthesis and their divergent transformations of aryltetrahydrofuran-type lignans. Tetrahedron Lett. 2023, 115, 154309. (Invited Review)
5. Han-Qiu Zhang, Chu-Xuan Yan, Jian Xiao*, Ya-Wen Wang, Yu Peng*. Recent Advances in the Total Synthesis of 2,7′-Cyclolignans. Org. Biomol. Chem. 2022, 20, 1623‒1636. (Invited Review; The Themed Collection: Total Synthesis in OBC)
4. Lai Zhang, Jian Xiao*, Yawen Wang, Yu Peng*. Recent Advances on the Construction of Chiral Dihydrobenzofurans by Asymmetric [3+2] Cyclization Reactions of Phenols (Quinones) and Alkenes. Acta Chim. Sinica. 2022, 80, 1152‒1164.
3. Yang Shang, Jian Xiao*, Yawen Wang, Yu Peng*. Advances on Asymmetric Construction of Diarylmethine Stereocenters. Acta Chim. Sinica. 2021, 79, 1303‒1319.
2. Jun Zhao, Jian Xiao*, Yawen Wang, Yu Peng*. Advances on the Synthesis of Natural Products with Dihydrobenzofuran Skeleton via Oxidative [3+2] Cycloadditions. Chin. J. Org. Chem. 2021, 41, 2933‒2945.
1. Jian Xiao, Yu Peng, Wei-Dong Z. Li*. Advances on the Total Synthesis of Sesquiterpenoid Alkaloid Dendrobine. Chin. J. Org. Chem. 2021, 41, 2636‒2649.
专利授权：
3. 一种螺苯并呋喃化合物制备方法 ZL 2020 1 0676321. 9 发明专利/中国
2. 一种抗癌药物先导物木脂素Aglacin B的制备方法 ZL 2022 1 0412657. 3 发明专利/中国
1. 一种拉坦前列素中间体的制备方法及其用途 ZL 2023 1 0289603.7 发明专利/中国