郭志云，男，山西大同人，四川大学生物治疗国家重点实验室博士毕业，宾夕法尼亚大学医学院博士后，西南交通大学生命科学与工程学院副教授，曾在军事医学科学院生物工程研究所从事研究工作。目前主要从事的领域为肿瘤生物信息学与药物基因组学。团队致力于通过生物信息与分子生物实验结合的方法对肿瘤调控机制、抗肿瘤药物、肿瘤标志物等进行研究。目前以第一或通讯作者在包括《Briefings In Bioinformatics》、《International Journal of Biological Sciences》、《Comput Biol Med》、《Bioinformatics》等国际顶级期刊发表40余篇SCI论文，获国家发明专利1项，软件著作权16项。主持主研包括国家自然科学基金、国家重大专项子课题项目、四川省科技厅重点项目、中央高校项目在内的多个科研项目。现任Frontiers in Genetics等杂志编委、中国抗癌协会甲基化标志物专家委员会委员，中国生物信息协会系统生物学与转化信息学专委会委员、四川省生物信息学会理事等职。Briefings in Bioinformatics、Molecular Biology and Evolution、Computers in Biology and Medicine等期刊审稿人。

研究领域：肿瘤生物信息学与药物基因组学

研究方向：

1、肿瘤调控机制与抗肿瘤药物分子机理（生物信息学+分子生物学实验）

2、抗肿瘤药物研发与肿瘤早期诊断

3、临床基因测序与多组学

4、人工智能应用下的精准医疗

5、分子模拟与药物设计

6、肿瘤免疫

7、非编码RNA结构与功能（microRNA，lncRNA等）

招收要求：

1、招收生物学、生物与医药、药学背景同学。无需有计算机技能，但需对未来研究方向有兴趣，有创造力！

2、报考相关请通过邮件（zhiyunguo@swjtu.edu.cn）咨询。

发表文章（2012-）:

1.      Wenqing Wang, Xinyu Zhao, Tianyu Ma, Tengwei Zhong, Junnuo Zheng, Zhiyun Guo，scEccDNAdb: an integrated single-cell eccDNA resource for human and mouse, Database (Oxford),2024, doi: 10.1093/database/baae126., (IF=5.8, JCR 1区)

2.      Xinyu Zhao, Huan Zhao, Yupeng Liu, Zhiyun Guo*，Methods, bioinformatics tools and databases in ecDNA research: An overview，Comput Biol Med, 2023 doi: 10.1016/j.compbiomed.2023.107680 (IF=7.7) (JCR 1区，顶级期刊)

3.      Tengwei Zhong, Wenqing Wang, Houyan Liu, Maolin Zeng, Xinyu Zhao, Zhiyun Guo*，eccDNA Atlas: a comprehensive resource of eccDNA catalog. Briefings In Bioinformatics，2023 Mar 19;24(2):bbad037. doi: 10.1093/bib/bbad037. (IF=13.994) (JCR 1区，顶级期刊)

4.      王文著，岳锐，郭志云*，支原体整合性接合元件基因组分析，军事医学. 2023,47(07)

5.      张雅娜，牟苑菁，李苇祥，赵俊焱，郭志云*,基于单细胞ATAC 测序数据的乳腺癌上皮细胞转录因子研究,生命科学研究，CSCD，2023-10-17

6.      唐瑜泽，张茵，钟腾纬，郭志云*，肝癌HepG2细胞中TEAD1-增强子调控微RNA的识别与分析，生命科学研究，CSCD，2023

7.      Qingqing Huang, Zhengtang Tan, Yanjing Li, Wenzhu Wang, Mei Lang, Changying Li, Zhiyun Guo*, TFcancer: a manually curated database of transcription factors associated with human cancer. Bioinformatics, 2021, 37(22), 4288–4290. (IF=6.931) (JCR 1区)

8.      Mingming Qian§, Wenzhu Wang§, Yana Zhang, Yi Zhao, Huige Quan,Yuting Chen, Xinyue Dai and Zhiyun Guo*, Identification and characteristic analysis of enhancers across 13 major cancer types, Precision Clinical Medicine, 2021, 4(3), 204–208, https://doi.org/10.1093/pcmedi/pbab019 (IF=5.3) (JCR 1区)

9.      Ran Kang, Zhengtang Tan, Mei Lang, Linqi Jin, Yin Zhang, Yiming Zhang, Tailin Guo, Zhiyun Guo*. EnhFFL: A database of enhancer mediated feed-forward loops for human and mouse. Precision Clinical Medicine, 2021, 4(2), 129–135, https://doi.org/10.1093/pcmedi/pbab006  (IF=5.3) (JCR 1区)

10.    钱明明;  谭政堂;  王文著;  李昶蓥;  邱正良;  郭志云*，乳腺癌增强子-miRNA调控网络识别与分析，生命科学研究，CSCD，2021，25（1）:64-69

11.   郎梅，郭志云*，DNAVec：基因组DNA序列的预训练词向量表示,生物医学, 2021, 11(3), 121-128

12.   Fei Tang, Yin Zhang, Qing-Qing Huang, Ming-Ming Qian, Zhi-Xue Li, Yan-Jing Li, Bei-Ping Li, Zheng-Liang Qiu, Jun-Jie Yue, Zhi-Yun Guo* , Genome-Wide Identification and Analysis of Enhancer-Regulated microRNAs Across 31 Human Cancers. Frontiers in Genetics, 2020. 11: p. 644 (IF=4.772). (JCR 2区)

13.   Yin Zhang, Mingming Qian, Fei Tang, Qingqing Huang, Wenzhu Wang, Yanjing Li,Zhixue Li, Beiping Li, Zhengliang Qiu, Junjie Yue and Zhiyun Guo*, Identification and Analysis of p53-Regulated Enhancers in Hepatic Carcinoma. Frontiers in Bioengineering and Biotechnology, 2020. 8: p. 668 (IF=6.064). (JCR 1区)

14.   黄晴晴，谭政堂，李昶蓥，邱正良，郭志云*.前列腺癌中致病基因与核心转录因子的识别与功能分析，中国肿瘤生物治疗杂志，CSCD，2020,27：895-900

15.   唐飞，王文著，郎梅，郭志云*，肝癌增强子-miRNA调控作用对的识别与特征分析，中国肿瘤生物治疗杂志，CSCD，2020,27：781-786

16.   张茵, 王文著, 谭政堂, 李昶蓥, 岳俊杰, 郭志云*，乳腺癌中p53调控增强子的特征与功能分析，生命科学研究，CSCD，2020,6：476-483

17.   蒙俊桦; 郎梅; 康冉; 张茵; 唐飞; 郭志云*，乳腺癌致病microRNA调控网络的识别与生物信息学分析,生物技术通讯, 2019, (03): 378-384.

18.   李志学，梁子涵，贾承霖，漆宇骋，岳俊杰，郭志云*，肺腺癌增强子调控miRNA 前馈环路的识别与功能分析，生物技术通讯，2019,6:16-21

19.   常允建; 康冉; 薛璇; 王韶畅; 赵庆文; 郭志云*，肝癌中增强子调控miRNA前馈环路的识别与功能分析,生物技术通报, 2019, (05): 140-145.

20.   Ran Kang, Yiming Zhang, Qingqing Huang, Junhua Meng, Ruofan Ding, Yunjian Chang, Lili Xiong, Zhiyun Guo*, EnhancerDB: A Resource of Transcriptional Regulation in the Context of Enhancers, Database (Oxford). 2019.doi: 10.1093/database/bay141 (IF=4.462)  (JCR 1区)

21.   Liu W, Huai R, Zhang Y, Rao S, Xiong L, Ding R, Mao C, Zhao W, Hao T, Huang Q, Guo Z*.Down-regulation expression of TGFB2-AS1 inhibits the proliferation, migration, invasion and induces apoptosis in HepG2 cells. Genes & Genomics. 2019 ，41(8):951-959 (IF=2.164)

22.   Xiong LL#, Kang R, Ding RF, Kang WY, Zhang YM, Liu WR, Huang QQ, Meng JH, Guo ZY*, Genome-wide Identification and Characterization of Enhancers Across 10 Human Tissues, International Journal of Biological Sciences. 2018 Jul 27;14(10):1321-1332 (IF=10.75).  (JCR 1区，顶级期刊)

23.   Rao S#*, Ghani M#, Guo Z#, Deming Y, Wang K, Sims R, Mao C, Yao Y, Cruchaga C, Stephan DA, Rogaeva E. An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk. Neurobiology of aging, 2018, S0197-4580(17)30424-4 (IF=5.133).(JCR 1区)

24.   Bi Z#, Liu W, Ding R, Wu Y, Dou R, Zhang W, Yuan X, Liu X, Xiong L, Guo Z*, Mao C*. A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression. European Journal of Pharmacology. 2017, 796:175-189.  (JCR 1区，顶级期刊)

25.   Yiming Zhang#, Ran Kang, Wenrong Liu, Yalan Yang, Ruofan Ding, Qingqing Huang, Junhua Meng, Lili Xiong*, Zhiyun Guo*. Identification and analysis of p53-mediated competing endogenous RNA network in human hepatocellular carcinoma. International Journal of Biological Sciences.2017, 13(9): 1213-1221 ( IF=10.75).  (JCR 1区，顶级期刊)

26.   Wenrong Liu#, Ruofan Ding, Yiming Zhang, Canquan Mao, Ran Kang, Junhua Meng, Qingqing Huang, Lili Xiong, Zhiyun Guo*. Transcriptome profiling analysis of differentially expressed mRNAs and lncRNAs in HepG2 cells treated with peptide 9R-P201. Biotechnology Letters. 2017, doi: 10.1007/s10529-017-2407-1. 39(11):1639-1647 (IF=2.716)

27.   李宇鹏，张一鸣，胡海碧，康成宇，李牧洲，郭志云*,肝癌细胞HepG2中p53调控miRNA-3661的生物信息，生物技术通报，2017，(07): 216-223 (CSCD)

28.   丁若凡，李宇鹏，张一鸣，朱小冬，胡海碧，刘文荣，李玲，郭志云*，肝癌细胞HepG2中增强子的识别及生物信息学分析，生物技术通讯，2017，(04): 455-459

29.   刘文荣，丁若凡，张一鸣，李宇鹏，李玲，郭志云*，抗肿瘤多肽9R-P201诱导下的肝癌HepG2 细胞转录组，生物技术通报，2017，(07): 210-215 (CSCD)

30.   Rao S#, Martínez-Cengotitabengoa M, Yao Y, Guo Z, Xu Q, Li S, Zhou X, Zhang F. Peripheral blood nerve growth factor levels in major psychiatric disorders. J Psychiatr Res. 2017, 86:39-45

31.   Yang Y#, Liu W, Ding R, Xiong L, Dou R, Zhang Y, Guo Z*. Comprehensive Expression Profiling and Functional Network Analysis of p53-Regulated MicroRNAs in HepG2 Cells Treated with Doxorubicin. PLoS One. 2016, 17;11(2):e0149227 (IF=3.752) (JCR 1区)

32.   Guo ZY#, Maki M, Ding RF, Yang YL, Zhang, B, Xiong, LL*. Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Scientific Reports. 2014, 3(4): 5150 (IF=4.996) (JCR 1区)

33.   Xiong LL#, Jang W, Zhou R, Mao CQ, Guo ZY*. Identification and analysis of the regulatory network of Myc and microRNAs from high-throughput experimental data. Computers in Biology and Medicine. 2013, 43(9):1252-1260 (IF=6.698)  (JCR 1区，顶级期刊)

34.   Wang XL#, Wang X, Xiong LL, Zhu Y, Chen HL, Wang XX, Li RL, Guo ZY, Li P, Jiang W*.: Salidroside improves Doxorubicin-induced cardiac dysfunction by suppression of excessive oxidative stress and cardiomyocyte apoptosis: Doxorubicin cardiotoxicity inhibited by salidroside. J. Cardiovascular Pharmacology 62(6): 512-523, 2013.

35.   Zhou R#, Huang WJ#, Guo ZY#, Li L, Tang M, Deng YQ, Li ZQ, Yang JY, Yang L, Tong AP*. Molecular mechanism of hepatocellular carcinoma-specific antitumor activity of novel thienopyridine derivative TP58. Oncology reports. 2012, 28(1):225-231. (IF=4.136)

36.   Tong XX#, Wu D, Wang X, Chen HL, Chen JX, Wang XX, Wang XL, Gan L, Guo ZY, Shi GX, Zhang YZ, Jiang W*. Ghrelin protects against cobalt chloride-induced hypoxic injury in cardiac H9c2 cells by inhibiting oxidative stress and inducing autophagy. Peptides 38(2): 217-222, 2012.

37.   Gan L, Jiang W., Xiao YF, Deng L, Gu LD, Guo ZY, Zhou ZC, Wu D, Xin HB*.: Disruption of CD38 gene enhances cardiac functions by elevating serum testosterone in the male null mice. Life Sciences 89(13): 491-497, 2011.

38.   Chen DZ, Li P, Guo WH, Ye F, Wu J, Wei DM, Guo ZY, Ye C*.: Molecular evolution of candidate sour taste receptor gene PKD1L3 in mammals. Genome 54(11): 890-897, 2011.

 

• 肿瘤调控机制与抗肿瘤药物分子机理
• 肿瘤药物作用机制、肿瘤早期诊断与抗肿瘤药物
• 临床基因测序与多组学
• 人工智能应用下的精准医疗