刘祥伟

个人信息Personal Information

职务: Principle Investigator/Group Leader

所在单位: 生命科学与工程学院

学历: 博士研究生毕业

办公地点: 九里校区3731 (Jiuli Campus-3731)

性别:

联系方式: 中国四川省成都市二环路北一段111号 (No. 111, North 1st Section, 2nd Ring Road Chengdu, Sichuan, China)

学位: 理学博士学位

电子邮箱: beyondlxw@hotmail.com

毕业院校: 中国科学院成都生物研究所

学科: 药学

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个人简介Personal Profile

Research ID: F-9378-2014 

ORCID: http://orcid.org/0000-0002-5647-6687 


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刘祥伟博士于2018年3月加入西南交通大学生命科学与工程学院从事教学科研工作,主要开展药物合成化学与有机合成化学相关的研究工作。


研究方向为药物化学导向的有机合成方法学发展,旨在将有机化学与药物化学有机结合,发展高效高选择性的分子构建新策略,并将所发展的方法应用于潜在活性分子库的构建及药物分子的后期结构修饰中,以及进一步的活性筛选和构效关系(SAR)研究。 


至今已在Journal of American Chemical SocietyAngewandte Chemie International EditionOrganic LettersThe Journal of Organic Chemistry,

Chemical CommunicationsChemistry-A European Journal, Chinese Journal of Organic Chemistry 等化学领域国际权威期刊发表学术论文多篇。 


先后主持并完成中国博士后科学基金项目(No. 2013M530464)和欧盟地平线项目玛丽居里博士后基金(H2020-MSCA-IF, No. 702563)项目,主研南开大学元素有机国家重点实验室开放基金项目等,目前主持国家自然科学基金青年项目及四川省科学技术厅面上项目。


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9.  Coming soon...


8.  "Base-Mediated Defluorosilylation of sp2 & sp3 C–F Bonds"

    Xiang-Wei Liu, Cayetana Zarate, Ruben Martin*

    Angew. Chem. Int. Ed. 2019, 58, 2064-2068

    (First Published: 21 December 2018), DOI:10.1002/anie.201813294

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7.  "Ni-Catalyzed Borylation of Aryl Fluorides via C–F Cleavage"

    Xiang-Wei Liu, Javier Echavarren, Cayetana Zarate, Ruben Martin*

    J. Am. Chem. Soc. 2015, 137, 12470-12473

    (Received 2 August 2015, Published online 23 September 2015, Published in print 7 October 2015)  Most read article in       JACS in September 2015

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6.  "Diversified Syntheses of Multifunctionalized Thiazole Derivatives via Regioselective and         

    Programmed C-H Activation"

    Xiang-Wei Liu, Jiang-Ling Shi, Jiang-Bo Wei, Chao Yang, Jia-Xuan Yan, Kun Peng, Le Dai, Chen- 

    Guang Li, Bi-Qin Wang, Zhang-Jie Shi*

    Chem. Commun. 2015, 51, 4599-4602.

    (The article was received on 09 Jan 2015, accepted on 04 Feb 2015 and first published on 04 Feb 2015)

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5.  "Palladium-Catalyzed C(sp3)-H Activation: A Facile Method for the Synthesis of 3,4- 

    Dihydroquinolinone Derivatives"

    Jia-Xuan Yan, Hu Li, Xiang-Wei Liu, Jiang-Ling Shi, Xin Wang, Zhang-Jie Shi*

    Angew. Chem. Int. Ed. 2014, 53, 19 4945-4949.

    (First published: 06 April 2014)

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4.  "Regioselective Arylation of Thiazole Derivatives at 5-Position via Pd Catalysis under Ligand-Free

    Conditions"

    Xiang-Wei Liu, Jiang-Ling Shi, Jia-Xuan Yan, Jiang-Bo Wei, Kun Peng, Le Dai, Chen-Guang Li, Bi-Qin Wang, Zhang-Jie Shi*

    Org. Lett. 2013, 15, 22 5774-5777.

    (Publication Date (Web): October 31, 2013)

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3.  "An Organocatalyst Bearing Stereogenic Carbon and Sulfur Centers as an Efficient Promoter for

    Enantioselective Hydrosilylation of 1,4-Benzooxazines"

    Xiang-Wei Liu, Chao Wang*, Yan Yan, Yong-Qiang Wang, Jian Sun*

    J. Org. Chem. 2013, 78, 12 6276-6280.

    (Publication Date (Web): May 29, 2013)




2. "Highly Enantioselective Reduction of β-Amino Nitroolefins with a Simple N-Sulfinyl Urea as     

   Bifunctional Catalyst"

   Xiang-Wei Liu, Yan Yan, Yong-Qiang Wang, Chao Wang, Jian Sun*

   Chem. Eur. J. 2012, 18, 30 9204-9207(First published: 26 June 2012)

   Highlighted by "N-Sulfinyl Urea as Bifunctional Catalyst: Hydrosilylation of β-Amino Nitroolefins",

   Benjamin List*, Manuel Mahlau Synfacts 2012, 8, 09 1022-1022.

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1. "Advances in Asymmetric Reduction of Prochiral Ketones Catalyzed by Diphenylprolinol and Its

   Derivatives"

   Xiangwei Liu, Xiabing Li, Baolin Li*

   Chin. J. Org. Chem. 2009, 29, 1325-1335.


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Profile:

Xiang-Wei Liu was born in Chongqing municipality in 1984.


He received his B. Sc in 2006 at Shaanxi University of Technology with Prof. Zhi-Hua Tang, M. Sc. in 2009 at Shaanxi Normal University with Prof. Bao-Lin Li and then Ph.D in 2012 at Chengdu Institute of Biology, Chinese Academy of Sciences with Prof. Jian Sun, working on the design, synthesis and application of novel Lewis base organocatalysts in asymmetric hydrosilylation of beta-amino nitroolefins and epimines.


In Septerber 2012 he moved to the College of Chemistry and Molecular Engineering, Peking Univeristy as a postdoctoral fellow with Prof. Zhang-Jie Shi, where he worked on the regioselective C-H functionalization of thiazole derivatives, during his time he successfully applied for the grant from China Postdoctoral Science Foundation.

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In May 2015 he undertook further postdoctoral studies at the Institute of Chemical Research of Catalonia (Institut Català d'Investigació Química, ICIQ) as a postdoctoral fellow with Prof. Ruben Martin where he developed new synthetic strategies for C-B and C-Si bond-forming reactions from inert C-F bond cleavage. During his time at ICIQ, he has successfully applied for the prestigious Marie Curie Post-doctoral Research Fellowship (MSCA).


In March 2018 he joined the School of Life Science and Engineering, Southwest Jiaotong University as an associate professor. His current research focuses on the development of methodologies toward the synthesis of active pharmaceutical ingredients. He is now supported by the grants from National Natural Science Foundation of China, Department of Science & Technology of Sichuan Province and the Fundamental Research Funds for the Central Universities


Funding:
National Natural Science Foundation of China, NSFC (CNY, No.21702172, 2018-2020)
Department of Science & Technology of Sichuan Province (CNY, No.2019YJ0218, 2019-2021)
The Fundamental Research Funds for the Central Universities (CNY, No.2682019CX75, 2019-2020) 
The Starting Grant from Southwest Jiaotong University (CNY, 2018-2023)
     
Past Funding:

China Postdoctoral Science Foundation (CNY, No. 2013M530464, 2013-2014)

Marie Skłodowska-Curie Individual Fellowships (MSCA-IF-2015-EF, No. 702563(€, 2016-2018)

Financial supports from the abovementioned agencies are gratefully acknowledged.

  • 教育经历Education Background
  • 工作经历Work Experience
  • 研究方向Research Focus
  • 药物合成化学;有机合成化学;元素有机化学;过渡金属催化