张强胜,特聘副研究员。2021年毕业于四川大学生物治疗国家重点实验室,获药物化学专业博士学位。近年来,作为项目负责人承担国家自然科学基金青年科学基金项目、中国博士后基金面上项目等5项,参与国家科技重大专项、国家自然科学基金等多项。以第一/通讯作者(含共同)在J.MED.CHEM.、CHEM.COMMUN.、EUR.J.MED.CHEM.、PHARMACOL.RES.等期刊发表SCI论文多篇(其中Top期刊论文12篇,含1篇ESI高被引论文、1篇Nature Index期刊论文)。任EUR.J.MED.CHEM.在内的多份国际SCI学术刊物审稿人。作为共同发明人申请中国发明专利3项(2项已授权)。
近年科研项目
(1) 国家自然科学基金青年科学基金项目,82304280,2024-01至2026-12, 主持。
(2) 中国博士后基金面上项目,2022M722288,2023-01至2024-12, 主持。
(3) 四川大学专职博士后研发基金,2022SCU12053,2022-01至2023-12, 主持。
(4) 四川大学博士后交叉学科创新启动基金,Z.Q.S.2021, B.Z.F.2021,2022-01至2023-12, 主持。
(5) 四川大学华西医院专职博士后基金,2021HXBH087,2022-04至2024-04, 主持。
(6) 国家自然科学基金面上项目,82373731,2024-01至2027-12, 主研1。
(7) 国家自然科学基金面上项目,22377086,2024-01至2027-12, 主研1。
(8) 国家自然科学基金面上项目,82073687,2021-01至2024-12, 主研4。
近年发表论文
(1) Qiangsheng Zhang1, Xinyi Chen1, Jiaying Cao, Wan Yang, Guoquan Wan, Qiang Feng, Shuyan Zhou, Hongling Yang, Ningyu Wang, Zhihao Liu, Hongtao Xiao, Yongxia Zhu*, Luoting Yu*. Discovery of a Novel Covalent EZH2 Inhibitor Based on Tazemetostat Scaffold for the Treatment of Ovarian Cancer. J Med Chem. 2023;66(3):1725-1741. (中科院分区:大类1区,小类1区,Top期刊,ESI高被引论文)
(2) Qiangsheng Zhang1, Xi Hu1, Lu Li1, Lidan Zhang, Guoquan Wan, Qiang Feng, Yongxia Zhu, Ningyu Wang*, Zhihao Liu*, Luoting Yu*. The discovery of SKLB-0335 as a paralog-selective EZH2 covalent inhibitor. Chem Commun. 2021;57(24):3006-3009. (Nature Index期刊)
(3) Qiangsheng Zhang, Lu Li, Siyan Li, Xianli Zhou*. Small molecule compounds targeting G9a/GLP: Recent advances and perspectives.2025;290:117525. (中科院分区:大类2区,小类1区,Top期刊)
(4) Qiangsheng Zhang, Hongling Yang, Qiang Feng, Jiaying Cao, Yiqian Zhang, Lu Li*, Luoting Yu*. Focus on the classical and non-classical functions of EZH2: Guide the development of inhibitors and degraders. Pharmacol Res. 2022;178:106159.(中科院分区:大类2区,小类1区,Top期刊,发表当年 IF >10)
(5) Qiangsheng Zhang1, Xi Hu1, Guoquan Wan, Jia Wang, Lu Li, Xiuli Wu, Zhihao Liu*, Luoting Yu*. Discovery of 3-(((9H-purin-6-yl)amino)methyl)-4,6-dimethylpyridin-2(1H)-one derivatives as novel tubulin polymerization inhibitors for treatment of cancer. Eur J Med Chem. 2019;184:111728. (中科院分区:大类2区,小类1区,Top期刊)
(6) Qiangsheng Zhang, Jiaying Cao, Yiqian Zhang, Zhenfei Bi, Qiang Feng, Luoting Yu, Lu Li*. Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors. Eur J Med Chem. 2023;247:115032. (中科院分区:大类2区,小类1区,Top期刊)
(7) Qiangsheng Zhang, Bo Chang, Qiang Feng, Lu Li*. Discovery of novel G9a/GLP covalent inhibitors for the treatment of triple-negative breast cancer. Eur J Med Chem. 2023;261:115841. (中科院分区:大类2区,小类1区,Top期刊)
(8) Qiangsheng Zhang, Xinyi Chen, Xi Hu, Xianjie Duan, Guoquan Wan, Lu Li, Qiang Feng, Yiqian Zhang, Ningyu Wang*, Luoting Yu*. Covalent inhibitors of EZH2: Design, synthesis and evaluation. Biomed Pharmacother. 2022;147:112617. (中科院分区:大类2区,小类1区,Top期刊)
(9) Qiang Feng, Luoting Yu, Lu Li*, Qiangsheng Zhang*. Covalent inhibitors meet epigenetics: New opportunities. Eur J Med Chem. 2024; 280:116951.(中科院分区:大类2区,小类1区,Top期刊)
(10) Lu Li*, Qiangsheng Zhang*. Insight into Structure-Activity Relationship of New Compounds for Breast Cancer Treatment. Curr Top Med Chem. 2023;23(25):2373-2393.
(11) Guoquan Wan1, Zhanzhan Feng1, Qiangsheng Zhang1, Xiao Li, Kai Ran, Huan Feng, Tianwen Luo, Shuyan Zhou, Chang Su, Wei Wei, Ningyu Wang, Chao Gao, Lifeng Zhao*, Luoting Yu*. Design and Synthesis of Fibroblast Growth Factor Receptor (FGFR) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Cancer. J Med Chem. 2022;65(24):16541-16569. (中科院分区:大类1区,小类1区,Top期刊)
(12) Zuli Hu1, Qiangsheng Zhang1, Zulong Li1, Hongling Yang, Xin Chen, Qi Zhang, Tianqiong Yang, Xiaojie He, Qiang Feng, Jun He, Luoting Yu*.Design, synthesis and antitumor activity of a novel FGFR2-selective degrader to overcome resistance of the FGFR2V564F gatekeeper mutation based on a pan-FGFR inhibitor. Eur J Med Chem. 2024:275:116612.(中科院分区:大类2区,小类1区,Top期刊)
(13) Hongling Yang1, Qiangsheng Zhang1, Shuyan Zhou, Zuli Hu, Qing Tang, Zulong Li, Qiang Feng, Luoting Yu*. Discovery of a first-in-class degrader for the protein arginine methyltransferase 6 (PRMT6). Bioorg. Chem. 2024. 107439. (中科院分区:大类2区,小类1区,Top期刊)
(14) Shuyan Zhou1, Qiangsheng Zhang1, Honglin Yang, Yongxia Zhu, Xiang Hu, Guoquan Wan, Luoting Yu*. Targeting type I PRMTs as promising targets for the treatment of pulmonary disorders: Asthma, COPD, lung cancer, PF, and PH. Life Sci. 2024;342:122538. (中科院分区:大类2区,小类2区,Top期刊)
(15) Yingyue Yang1, Xiaojie He1, Zulong Li1, Kai Ran, Ningyu Wang, Lifeng Zhao, Zhihao Liu, Jun Zeng, Bo Chang, Qiang Feng, Qiangsheng Zhang*, Luoting Yu*. Design, synthesis and biological evaluation of indazole derivatives as selective covalent inhibitors of FGFR4 in wild-type and gatekeeper mutants. Eur J Med Chem. 2023;258:115628.(中科院分区:大类2区,小类1区,Top期刊)
(16) Guoquan Wan1, Huan Feng1, Chang Su, Yongxia Zhu, Lidan Zhang, Qiangsheng Zhang*, Luoting Yu*. A patent review of EZH2 inhibitors from 2017 and beyond. Expert Opin Ther Pat. 2023;33(4):293-308. (中科院分区:大类2区,小类2区)
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