Yang Shiping
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Supervisor of Master's Candidates
- Master Tutor
- Gender:Male
- Education Level:PhD graduate
- Degree:Doctor of science
- Business Address:西南交通大学九里校区3号教学楼3105
- Status:在岗
- Academic Titles:特聘研究员
- Alma Mater:四川大学
- Supervisor of Master's Candidates
- School/Department:医学院
Contact Information
- Email：
- Paper Publications
A dual-twisted molecular strategy achieves dramatic quantum-yield enhancement in NIR-II AIEgen for high-performance bioimaging
- Impact Factor:13.6
- DOI number:10.1016/j.biomaterials.2026.124404
- Journal:Biomaterials
- Key Words:Dual-twisted strategy Fluorescence imaging NIR-II AIEgens Non-radiative decay
- Abstract:Developing NIR-II AIEgens with high fluorescence efficiency offers significant potential to revolutionize disease diagnosis and monitoring. However, existing designs largely rely on twisted donor–acceptor, donor–π-bridge, or acceptor–π-bridge motifs. Although twisted dual-acceptor architectures provide a fresh paradigm, reliance on a single twisted component has limited structural diversity and capped performance gains, necessitating innovative design philosophy. Here, we introduce a dual-twisted strategy that integrates two distinct types of twisted elements, namely a twisted dual-acceptor and a distorted acceptor–π bridge, within a single fluorophore. Compared with its single-twist analogue, the dual-twisted 2TT-o2BBTD exhibits not only an enhanced AIE effect but also a remarkable improvement in relative quantum yields (QY). Specifically, its relative QY is 7.6 times higher in solution and 27.5 times higher in the aggregate state than that of the control molecule. Mechanistic studies reveal that the dual-twisted design strengthens intermolecular interactions, mitigates intramolecular motions, and weakens nonradiative decay, thereby drastically boosting fluorescence emission. Leveraging these advantages, 2TT-o2BBTD NPs enable high-quality visualization of whole-body vasculature, the mesenteric system, tumor resection process, and cerebrovascular network. Collectively, this work presents the first evidence that the dual-twisted tactic could serve as a new design direction for the AIE development, delivering stronger packing, superior AIE effect, and improved bioimaging performance.
- Indexed by:SCI
- Volume:335
- Page Number:124404
- Translation or Not:no
- Date of Publication:2026-06-25
- Included Journals:SCI
- Links to published journals:https://www.sciencedirect.com/science/article/pii/S014296122600428X?via%3Dihub